FREE Shipping On All Orders Over $100
Pharmacist compounding medications

Health Implications of Magnesium Deficiency: Understanding the Impact on the Body

May 19, 2023


Magnesium is an essential mineral that plays a vital role in numerous physiological processes within the human body. From supporting energy production to maintaining healthy bones and muscles, magnesium is involved in various enzymatic reactions. However, many individuals experience magnesium deficiency without even realizing it, which can have significant health implications. We will explore the health consequences of magnesium deficiency, understand its impact on different bodily systems, and highlight the importance of maintaining optimal magnesium levels.

Magnesium Deficiency and its Prevalence

Magnesium deficiency, also known as hypomagnesemia, occurs when the body does not obtain enough magnesium to meet its needs. This deficiency can result from inadequate dietary intake, impaired absorption, increased excretion, or certain medical conditions. Despite its importance, magnesium deficiency is a common health concern, with studies suggesting that a significant proportion of the population may be deficient.

Impact on Cardiovascular Health

Magnesium plays a crucial role in maintaining cardiovascular health. It helps regulate blood pressure, supports the normal functioning of the heart, and contributes to the relaxation and dilation of blood vessels. Magnesium deficiency can lead to hypertension (high blood pressure), abnormal heart rhythms, and an increased risk of cardiovascular disease. Ensuring adequate magnesium levels is vital for maintaining optimal cardiovascular function.

Influence on Musculoskeletal System

The musculoskeletal system heavily relies on magnesium for its proper functioning. Magnesium is essential for muscle contraction and relaxation, as well as the synthesis of proteins involved in bone formation. Inadequate magnesium levels can contribute to muscle cramps, spasms, and weakness. Additionally, magnesium deficiency is associated with an increased risk of osteoporosis, a condition characterized by weak and brittle bones. Sufficient magnesium intake is crucial for supporting healthy muscles and maintaining strong bones.

Effects on Mental Health and Well-being

Magnesium plays a significant role in mental health and well-being. It acts as a co-factor in the synthesis of neurotransmitters involved in mood regulation, such as serotonin. Studies have linked magnesium deficiency to an increased risk of anxiety, depression, and other mood disorders. Ensuring optimal magnesium levels may contribute to better mental health, improved mood stability, and overall well-being.

Impact on Energy Metabolism

Magnesium is involved in numerous enzymatic reactions that are essential for energy metabolism. It contributes to the production and utilization of adenosine triphosphate (ATP), the body's primary energy currency. Inadequate magnesium levels can impair energy production, leading to fatigue, weakness, and decreased physical performance. Optimal magnesium status is vital for maintaining adequate energy levels and supporting optimal metabolic function.

Implications for Overall Health and Disease Risk

Magnesium deficiency has been associated with an increased risk of several chronic conditions, including type 2 diabetes, metabolic syndrome, and cardiovascular disease. Magnesium plays a role in insulin regulation, glucose metabolism, and lipid metabolism. Insufficient magnesium levels can disrupt these processes, contributing to insulin resistance, elevated blood sugar levels, and abnormal lipid profiles. By maintaining adequate magnesium levels, individuals can potentially reduce their risk of these chronic diseases.


Magnesium deficiency can have profound health implications, impacting various bodily systems and increasing the risk of chronic conditions. From cardiovascular health to mental well-being and energy metabolism, magnesium plays a critical role in maintaining optimal bodily function. Ensuring sufficient magnesium intake through a balanced diet rich in magnesium-containing foods or supplementation, when necessary, is crucial for promoting overall health and well-being. By prioritizing magnesium levels, individuals can take proactive steps toward maintaining a healthy lifestyle and reducing the risk of associated health complications.

The magnesium supplement I recommend to most people is either magnesium glycinate or magnesium citrate, 400-500mg, 1 hour before initiating sleep. These two formulations are also useful for constipation. Both of these formulations have high bioavailability, much higher than the more common, cheaper form you often find at the store, magnesium oxide.

June 16, 2023
The Power of a High-Quality Multivitamin in Supporting Glandular Health and Delaying Dementia Symptoms
fist punching virus to illustrate immune system fighting off infection
March 28, 2024
7 Ways to Boost Your Immune System
March 31, 2023
Why I Chose Functional Medicine
heart-shaped plate filled with heart-healthy foods
February 8, 2024
Top 7 Foods That Are Great for Heart Health