Musculoskeletal Health

Membrane Mend

Feed the Brain of Your Cells – High-grade PC and Ahiflower® fatty acid complex sync perfectly to help build and repair membranes. We need this smart barrier to maintain a healthy, energy-producing environment and keep out unwanted molecules, ions, and oxidative threats. Support Cellular Longevity – Potentially harmful inflammatory activity — a hallmark of aging — happens within our cells, too. The powerful antioxidant effects of astaxanthin, vitamin E, and fatty acids in Membrane Mend work fluidly to help balance inflammation at a cellular level. Uncover Energy Potential – The mini energy factories of our cells, mitochondria, have their own biological membranes. Because these powerhouses the energy “currency” used by every cell and tissue in the body, we need mitochondrial membranes to remain intact and functioning well at all times. Every cell and organelle in the human body is encapsulated by a lipid membrane that serves as the initiation point for intracellular signaling pathways. A number of modern-day factors such as toxin exposure, poor diets, and ongoing stress can disrupt the integrity and health of the cell’s membranes. Membrane Mend is a nanoemulsified blend of phosphatidylcholine; a major constituent of all cell membranes, the plant-based essential fatty acid Ahiflower® astaxanthin; and tocotrienols designed to promote the health and resilience of the cell and organelle membranes.

Membrane Mend Product Details

CoQ10

CoQ10 (short for coenzyme Q10, also known as ubiquinone) is the only fat-soluble antioxidant our bodies make—found in abundance in all of our fifty trillion cells’ lipid-rich membranes. It is essential to producing ATP, the universal energy currency of our cells. Maintaining adequate levels of CoQ10 is a key part of supporting overall health.* <ul> <li>Protects against oxidative stress*</li> <li>Supports cardiovascular health*</li> <li>Potent antioxidant properties*</li> </ul> <ul class="a-unordered-list a-vertical a-spacing-mini"> <li>Gastrointestinal absorption of CoQ10 is dramatically improved with a nanoemulsified format.*</li> <li>CoQ10 is essential to producing ATP, the universal energy currency of our cells. Maintaining adequate levels of CoQ10 can be a key part of supporting overall health.</li> <li>Each 1 mL of Liposomal CoQ10 delivers 30 mg of CoEnzyme Q10.</li> <li>With the world’s most advanced phospholipid delivery systems, Quicksilver Scientific supplements nourish cells as they deliver their core ingredients faster and more efficiently.</li> <li>This product uses phospholipids from purified sunflower seed lecithin and does not contain gluten.</li> </ul>

CoQ10 Product Details

Thymosin

Thymosin Beta-4-Frag 500+ is a synergistic blend of Acetyl-N-Ser-Asp-Lsy-Pro (AcSDKP), a biologically active fragment of Thymosin Beta-4 (TB-4) and Thymogen (Glu-Trp) which is a bioregulator dipeptide. These orally bioavailable peptides are combined with salcaprozate sodium (SNAC) for enhanced absorption. The fragment featured in this formula has been found to be 10x more potent compared to the full-length TB-4 by weight. Research has confirmed its regenerative potential, immune modulation, supportive role for gut health, inflammaging and fibrosis. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that has been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) nine-fold without affecting tight junctions. Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption without compromising its stability or efficacy.

Thymosin Product Details

Resolve+

Aging is characterized by an increase in the concentration of inflammatory markers in the blood- stream, a phenomenon that has been termed “inflammaging”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low-grade inflammation is likely to be detrimental for many tissues and for normal functions. Our team investigated various natural solutions targeting multiple influences of inflammaging. Resolve+ contains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms. Acmella oleracea (“jambu”) is sourced from Sardinia, Italy and rich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth. Acmella oleracea has been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides and cannabinoid type 2 (CB2) activation. There are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of Acmella. Studies reported in this review confirmed activities of Acmella, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α. Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L.), has been well documented to exhibit various health benefits. There have been many claims on the health benefits of curcumin on neurological, cardiovascular, lung, metabolic, and liver function, mainly through its anti-inflammatory and antioxidant properties. Despite its promising potential, the clinical application of curcumin has been limited due to its low bioavailability. To enhance curcumin absorption, we are the first to feature Theracurmin Super® 85X, a proprietary curcumin utilizing the latest technology that transforms standard curcumin into an amorphous structure. Theracurmin Super® 85X uses the latest technology to transform regular curcumin particles into a more bioavailable structure. This is done by splitting curcumin particles’ crystal structure amorphous, therefore, making it easily absorbed and bioavailable to maximize its supportive potential. Tetrahydrocurcumin (4-HC) is the key bioactive derivative of curcumin, it’s also given credibility as the engine behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that 4-HC attenuated pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-⍺, and prostaglandin E2. After reviewing the data, we found many advantages to infuse tetrahydrocurcumin as CurcuPrime® stacked with Theracurmin Super® 85X into Resolve+. Quercetin is a well-known studied dietary flavonoid ubiquitously present in various vegetables. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production. Multiple studies have confirmed its supportive potential as an immune modulator and its ability to support a healthy inflammatory response. It can improve the Th1/Th2 balance, and restrain antigen specific IgE antibody formation However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology which we feature in resolve is the preferred delivery system to overcome these limitations. This enhanced form of quercetin has been shown to be as much as 20 times better absorbed than other quercetin options. Casperome® boswellia phytosome is a potent extract made from the resin of Boswellia serrata trees and is also referred as Indian frankincense. Boswellia extracts have been demonstrated to be effective in the management of various inflammatory response functions including those that occur in the bowel, joints, bones, respiratory airways and in the brain. The mechanism of action that involves the modulation of the natural inflammatory response both acting on prostanoid synthesis (mPGE2S) and protein degradation (caspases), and transcription factors (Nf-κB). We have selected Casperome® which is a highly standardized in boswellic acids to match the natural composition of boswellia, formulated with phytosome technology to achieve optimized absorption and has been validated by over 10 human studies. Perilla frutescens is an annual herb belonging to the mint family (Lamiaceae). It is mainly produced in countries like China, Japan, India, Thailand and Korea. Recently, Perilla is gaining more attention because of its medicinal benefits and phytochemical contents. The functional compounds of Perilla Seed Extract are flavonoid Aglycons – polyphenols such as Luteolin, Apigenin, Chrysoeriol, and Rosemarinic Acid. Studies have shown that Perilla seed polyphenols regulate allergic and inflammatory response due to its 5-lipoxygenase inhibitory activity and suppression potential of histamine release from mast cells. AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has been shown to provide full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a health. AstraGin® has been shown in numerous studies to increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. Additionally, AstraGin® was shown to reduce intestinal inflammatory biomarker MPO, the pro-inflammatory cytokines IL-6, IL-17, and IL-1β in ulcerative colitis patients.

Resolve+ Product Details

Protect+ 10

This exclusive formula is designed to support the balance and absorption of fat-soluble vitamins in the body. Help protect your bones, heart, immune health and much more with Protect+.* This unique, high-potency formula features: <ul> <li>300mcg of a double micro-encapsulated bioactive all-trans K2VITAL Delta MK-7 </li> <li>250 mcg (10,000 IU) of vitamin D3 </li> <li>Efficacious amounts of vitamin A and vitamin E </li> <li>AstraGin (astragalus membranaceus and panax notoginseng) to promote maximum absorption and delivery of fat soluble vitamins in the body </li> </ul> Vitamin K2 (MK-7) Vitamin K2 is an essential nutrient that plays a vital role in many biological processes. Western diets are limited in vitamin K2, so vitamin K2 must be obtained through supplementation as well. K2 activates proteins involved in calcium metabolism, including osteocalcin, controlling the transport and distribution of calcium from arteries and soft tissues into bones. Among all of the K vitamins, vitamin K2 MK-7 exhibits the best bioavailability and longest half-life, with a half-life of 72 hours compared to two hours observed with K1. Due to its quick uptake and long half-life, K2 MK-7 reaches bones and vessel walls more easily, resulting in more effective activation of proteins, like osteocalcin. Osteocalcin proteins in the body must be activated to distribute calcium to our bones. These proteins are unlocked and activated by all-trans K2 MK-7. Protect+ contains >99% of the double micro-encapsulated bioactive form of vitamin K2 MK-7, identical to the all-trans K2 MK-7 found in nature and is fully bio-active providing the full benefits of vitamin K2 MK-7. <img src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/hydrovita-k2_480x480.jpg?v=1661869348" alt=""> Some supplements containing cis MK-7 are still available on the market, despite it being considered biologically inactive and therefore potentially ineffective. Due to the shape of the molecule, cis MK-7 cannot bind to the sites of enzymes, meaning the vitamin K-dependent proteins remain inactivated. On the other hand, all-trans MK-7 is bioactive, therefore it is important for supplements to include the highest possible percentage of this form of vitamin to achieve the desired health benefits. <img src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/Screen_Shot_2022-09-22_at_8.59.46_AM_480x480.png?v=1663851623" alt=""> Areas of clinical interest and potential roles for MK-7: Most of the new published research has been with higher dosing featured in Protect+ and has been demonstrating effects on new pathways, proteins, and cells. This includes ATP function in mitochondria, antioxidant effects, cardiovascular function, brain health, gut health, and more. <img src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/2_480x480.png?v=1660208397" alt=""> Vitamin D Recent research suggests that vitamin D supplementation may help promote cellular health and healthy aging. Vitamin D3 works by increasing the amount of calcium absorbed from the small intestine, helping to form and maintain bones. Vitamin D benefits the body by playing a role in immunity and controlling cell growth. Vitamin D has been shown to support biochemical processes linked to aging, including a healthy inflammatory response, autophagy, cell signaling, anti oxidative status and telomere integrity. There is growing evidence of the role Vitamin D may have in protecting against osteoporosis, high blood pressure, immunity, and many other health conditions. Vitamin A Vitamin A is a nutrient that is essential for many different functions in the human body. Vitamin A, also known as retinol, plays an important role in bone growth, tooth development, reproduction, cell division, gene expression, and regulation of the immune system. Vitamin A is also necessary for the maintenance of healthy skin, eyes, and mucous membranes. Vitamin A deficiency can lead to a number of serious health problems, including blindness, poor wound healing, and increased susceptibility to infections. Vitamin A is also an important antioxidant that may play a role in prevention and healthy aging. Vitamin E Vitamin E is an important nutrient that offers a range of benefits for the body. Vitamin E acts as an antioxidant, which means it helps to protect other nutrients from damage. For example, vitamin E helps to protect vitamins A and C, as well as essential fatty acids, from destruction. Vitamin E also helps to protect red blood cells from damage. This is important because red blood cells are responsible for carrying oxygen around the body. AstraGin® AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has shown in over a dozen in-vitro studies to improve the absorption of vitamins, amino acids, peptides, folate, glucosamine and other nutrients in Caco-2 cell, the gold standard used by drug companies to study the absorption of new drugs.

Protect+ 10 Product Details

Protect 5+

This exclusive formula is designed to support the balance and absorption of fat-soluble vitamins in the body. Help protect your bones, heart, immune health and much more with Protect+.* This unique, high-potency formula features: <ul> <li>300mcg of a double micro-encapsulated bioactive all-trans K2VITAL Delta MK-7 </li> <li>125 mcg (5,000 IU) of vitamin D3 </li> <li>Efficacious amounts of vitamin A and vitamin E </li> <li>AstraGin (astragalus membranaceus and panax notoginseng) to promote maximum absorption and delivery of fat soluble vitamins in the body </li> </ul> Vitamin K2 (MK-7) Vitamin K2 is an essential nutrient that plays a vital role in many biological processes. Western diets are limited in vitamin K2, so vitamin K2 must be obtained through supplementation as well. K2 activates proteins involved in calcium metabolism, including osteocalcin, controlling the transport and distribution of calcium from arteries and soft tissues into bones. Among all of the K vitamins, vitamin K2 MK-7 exhibits the best bioavailability and longest half-life, with a half-life of 72 hours compared to two hours observed with K1. Due to its quick uptake and long half-life, K2 MK-7 reaches bones and vessel walls more easily, resulting in more effective activation of proteins, like osteocalcin. Osteocalcin proteins in the body must be activated to distribute calcium to our bones. These proteins are unlocked and activated by all-trans K2 MK-7. Protect+ contains >99% of the double micro-encapsulated bioactive form of vitamin K2 MK-7, identical to the all-trans K2 MK-7 found in nature and is fully bio-active providing the full benefits of vitamin K2 MK-7. <img alt="" src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/hydrovita-k2_480x480.jpg?v=1661869348" data-mce-src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/hydrovita-k2_480x480.jpg?v=1661869348"> Some supplements containing cis MK-7 are still available on the market, despite it being considered biologically inactive and therefore potentially ineffective. Due to the shape of the molecule, cis MK-7 cannot bind to the sites of enzymes, meaning the vitamin K-dependent proteins remain inactivated. On the other hand, all-trans MK-7 is bioactive, therefore it is important for supplements to include the highest possible percentage of this form of vitamin to achieve the desired health benefits. <img alt="" src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/Screen_Shot_2022-09-22_at_8.59.46_AM_480x480.png?v=1663851623" data-mce-src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/Screen_Shot_2022-09-22_at_8.59.46_AM_480x480.png?v=1663851623"> Areas of clinical interest and potential roles for MK-7: Most of the new published research has been with higher dosing featured in Protect+ and has been demonstrating effects on new pathways, proteins, and cells. This includes ATP function in mitochondria, antioxidant effects, cardiovascular function, brain health, gut health, and more. <img alt="" src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/2_480x480.png?v=1660208397" data-mce-src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/2_480x480.png?v=1660208397"> Vitamin D Recent research suggests that vitamin D supplementation may help promote cellular health and healthy aging. Vitamin D3 works by increasing the amount of calcium absorbed from the small intestine, helping to form and maintain bones. Vitamin D benefits the body by playing a role in immunity and controlling cell growth. Vitamin D has been shown to support biochemical processes linked to aging, including a healthy inflammatory response, autophagy, cell signaling, anti oxidative status and telomere integrity. There is growing evidence of the role Vitamin D may have in protecting against osteoporosis, high blood pressure, immunity, and many other health conditions. Vitamin A Vitamin A is a nutrient that is essential for many different functions in the human body. Vitamin A, also known as retinol, plays an important role in bone growth, tooth development, reproduction, cell division, gene expression, and regulation of the immune system. Vitamin A is also necessary for the maintenance of healthy skin, eyes, and mucous membranes. Vitamin A deficiency can lead to a number of serious health problems, including blindness, poor wound healing, and increased susceptibility to infections. Vitamin A is also an important antioxidant that may play a role in prevention and healthy aging. Vitamin E Vitamin E is an important nutrient that offers a range of benefits for the body. Vitamin E acts as an antioxidant, which means it helps to protect other nutrients from damage. For example, vitamin E helps to protect vitamins A and C, as well as essential fatty acids, from destruction. Vitamin E also helps to protect red blood cells from damage. This is important because red blood cells are responsible for carrying oxygen around the body. AstraGin® AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has shown in over a dozen in-vitro studies to improve the absorption of vitamins, amino acids, peptides, folate, glucosamine and other nutrients in Caco-2 cell, the gold standard used by drug companies to study the absorption of new drugs.

Protect 5+ Product Details

Longevity

Biological aging is directly impacted by physiological integrity. Muscle strength, mass, function, quantity, and quality loss are some of the main issues associated with the process of aging. As we age the performance of our muscle cells decline which leads to a weakened immune system, sarcopenia, obesity, and chronic disease among much more. Healthgevity has selected PeptiStrong™, Senactiv® and AstraGin® which are all clinically proven ingredients to put your muscles in the best position to thrive regardless of your age. In a recent study it was concluded that lower muscle strength in late adolescence showed direct connection with higher risk of chronic disease. As such, skeletal muscle might be the central integrator between sarcopenia, obesity, immune senescence and more in an aging biological system. Preserving muscle mass is critical for optimizing health span. Research shows the strongest one-third of the population over the age of 60 has a 50% lower death rate than the weakest, making muscle a key predictor of longevity. Recent discoveries of clinically proven ‘growth promoting’ ingredients have made the process of building and preserving muscle more obtainable. PeptiStrong™, Senactiv® and AstraGin® work synergistically to target multiple mechanisms, to provide a wide range of benefits in muscle health. PeptiStrong™ (Peptides from hydrolyzed fava bean protein) Through cutting edge Al-precision technology, Nuritas is creating a brand-new category of precision peptide ingredients from nature. Their cell-signaling power helps the body function at its best. Longevity is the first product resulting from Healthgevity's collaboration with Nuritas and contains PeptiStrong™ : precision peptides that have been clinically proven to support muscle health. PeptiStrong™ can increase muscle synthesis by supporting mTOR, reduce muscle loss by downregulating muscle atrophy related genes and improve muscle health by reducing inflammation properties. Backed by two peer-reviewed clinical studies, this plant-based intelligent ingredient has outperformed animal protein. It has a multi-dimensional effect on muscle health: promoting muscle strength, improving recovery after intense exercise, boosting energy, and supporting the synthesis of protein that assists in maintaining and building muscle. A 'peptide-specific’ effect to address the muscle homeostasis between muscle protein synthesis, muscle atrophy and inflammation, offers an alternative to a purely uncharacterized nutritional intervention. In the most recent double blind placebo clinical study, PeptiStrong™ alone provided: Featured PeptiStrong™ research benefits: <ul> <li>Regenerates muscles by increasing the expression of new muscle fibers.</li> <ul> <li>Type I “Slow Twitch” Muscle Fibers are responsible for endurance and strength endurance. They contain a higher number of mitochondria and utilize fat for energy.</li> <li> Type II “Fast Twitch” Muscle fibers are responsible for strength and force production. Loss of Type II fibers is most associated with aging. </li> </ul> <li>Reduces muscle loss and fat accumulation</li> <li> Reduces Tumor Necrosis Factor-alpha (TNF-α) </li> <li>Improves cellular metabolism through the activation of AMPK which in turn increases the levels of NAD+ and sirtuins</li> <li>Maintains autophagy in skeletal muscle similar to fasting</li> <li>Induces mitochondrial biogenesis in the muscle cell</li> </ul> <div><img src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/Screenshot2023-02-09at9.28.50AM_1024x1024.png?v=1675952967"></div> Senactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) extracts containing ginsenoside Rg1: Senactiv® has over 10 years of research behind it including 2 in vivo studies and 5 human clinical trials. A recent study confirmed a process to reverse aging in muscle cells. Aging in muscle cells is a function of a cell itself, not being able to divide and repair itself. The process is known as cellular senescence, and it happens during aging. This study found that by the overexpression of a particular protein called NANOG, the cell does not have be reset to a different state to reverse aging. Ginsenoside Rg1 contained in Senactiv®, has the potential to activate expression of NANOG to help in reversing the aging process in skeletal muscle. A new mechanism of aging has been uncovered by researchers: the accumulation of sphingolipids. Ceramides, a widely known class of sphingolipids, build up in aging muscle and reduce its function, impacting the functional capacity of older adults. Senactiv® has the potential to inhibit sphingolipid synthesis prevent age-related decline in muscle mass and reduce its function. Senactiv® has been also shown to have the potential to: <ul> <li>Increase endurance performance</li> </ul> <ul> <ul> <ul> <li>endurance performance was extended by increasing energy in cells and increasing glycogen replenishment in muscles</li> </ul> </ul> </ul> <ul> <li>Speed up muscle fatigue recovery</li> </ul> <ul> <ul> <ul> <li>speeding up muscle fatigue recovery can be achieved by decreasing muscle inflammation during exercise and accelerating muscle inflammation recovery after exercise</li> </ul> </ul> </ul> <ul> <li>Muscle regeneration</li> </ul> <ul> <ul> <ul> <li>muscle regeneration was increased by eliminating senescent cells and increasing new muscle growth</li> </ul> </ul> </ul> AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1: AstraGin® has been shown to increase intestinal arginine and leucine absorption by 67% and 58%, respectively, which contributes to the activation of the mTOR pathway and suggest increasing the skeletal muscle protein synthesis by up to 30%. Recent studies show that the gut-muscle axis is a physiological target for combatting anabolic resistance and reducing risk of sarcopenia. AstraGin® has shown in 16 in-vitro and 8 in-vivo studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to: <ul> <li>Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. </li> <li>Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS- induced colitis rats. </li> <li>May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate. </li> <li>May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut- associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages. </li> </ul>

Longevity Product Details

Ignite+

Ignite+ is an exclusive breakthrough formula combining the leading ingredients available to increase metabolism, improve insulin signaling, body composition, reduce uptake of glucose into our bodies, and so much more. One of the best ways to prevent insulin resistance is to help remove excess glucose from our blood. We are the first to pair these several effective glucose disposal agents together to target several vital pathways that regulate metabolic efficiency. Ignite+ is an advanced metabolic optimization formula whose ingredients have been shown to support: <ul> <li>Reduction of adiposity and visceral fat*</li> <li>Increase thermogenesis by raising the metabolic rate and calorie burning*</li> <li>Browning of white adipose tissue*</li> <li>Diet-induced weight gain*</li> <li>Increase fatty acid oxidation*</li> <li>Ramp up ketone levels*</li> <li>Improves glucose tolerance and glucose control*</li> <li>AMPK activation*</li> <li>Leptin and ghrelin levels*</li> <li>Regulation of a healthy metabolism and mitochondrial health*</li> </ul> <header class="section-header"> <h1 class="section-header__title"><a href="https://healthgev.com/pages/what-makes-ignite-so-impactful">WHAT MAKES IGNITE+ SO IMPACTFUL?</a></h1> </header> <div class="rte rte--nomargin"> First, we have included InnoSlim®, a proprietary blend of purified, fractionated extracts of Panax notoginseng and Astragalus root produced by a pharmaceutical-grade extraction technology which delivers astragalosides and ginsenosides Rg1 and Rb1. Research has shown it supports the production of adiponectin, a protein hormone that helps modulate metabolic processes such as glucose regulation and fatty acid metabolism. InnoSlim® reduces glucose absorption in the intestine by 42%. This means that only 58% of the glucose you eat will be absorbed in your intestine. In addition, InnoSlim® also increases glucose absorption in muscle and fat cells by 50% and 68% by upregulating GLUT4 transporters, which takes glucose from our blood and transfers it into the muscle tissue. InnoSlim® has also been shown to support appetite control, AMPK activation, insulin resistance, triglycerides and sdLDL in cell, animal and human studies. One other mechanism Ignite targets to improve our metabolic health and weight is to increase the energy expenditure of our bodies. Ignite delivers several ingredients in the formula which help our bodies do this process. Each of these has unique mechanisms of action but combine to make massive differences in the energy we use and how we process glucose in our bloodstream. <ul> <li> MitoBurn® (L-BAIBA): Mitoburn® is an exercise mimetic, which mimics exercise’s effect on our tissues. This signals the body to help reduce fatty acids in our system, which are another energy source other than glucose. It can also help produce ketones which reduce appetite and improve energy output. It has also been shown to: Assist in the browning of white fat, activating AMPK, increasing metabolic rate, supporting leptin levels, and insulin resistance.</li> <li> GlucoVantage® Dihydroberberine: Dihydroberberine is a new version of traditional berberine that is up to 5x more bioavailable/absorbable and 2x longer lasting (8 hours vs. 4 hours). In one study, this led to 25.9% reduced blood glucose levels compared to the start of the trial in many patients. Dihydroberberine can also help with advanced glycation end products correlated with aging while supporting blood glucose disposal and improving insulin sensitivity and body composition.</li> <li> <div> DNF-10 satiety peptide complex is obtained from a screening of small molecular weight peptides (<10 kDa) after proteolysis of Saccharomyces cerevisiae, a non-pathogenic yeast. The peptides from DNF-10 lower the hypothalamic expression of neuropeptide Y and downregulate ghrelin, thereby reducing the physiological hunger cues confirmed in multiple published studies. </div> </li> <li> CalorieBurn GP® Grains of Paradise seed extract (6-Paradol 12.5%): CalorieBurn® contains bioactive compounds 6-paradol, 6-shogaol, 6-gingerol, and 6- gingerdione. These have been shown to effectively trigger highly thermogenic Brown Adipose Tissue (BAT) when taken in a precise ratio to one another, resulting in a 5X increase in calories burned over 2 hours compared to placebo. On average, burned 97 kcal more calories daily and lost more visceral fat. In another study, 40mg results in a 400% increase in metabolic rate within 30 minutes. Administration of this also reverses the unbalanced gut microbiota composition induced by a high-fat diet with a decrease in Firmicutes / Bacteroidetes ratio and increase in general Bifidobacterium and Akkermansia. </li> <li> Factor21® (Bitter Melon Extract): Factor21® is a natural regulator of a hormone growth factor called Fibroblast Growth Factor 21 (FGF21) and is an AMPK activator. FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses. Recent studies have revealed that supporting FGF21 can alleviate many age-related metabolic disorders. Factor21® is also an exercise mimetic that has many actions, including improved insulin secretion to drive glucose out of the bloodstream and inhibit fat cell growth.</li> <li> Actiponin® (gynostemma pentaphyllum extract): Actiponin® is a patented, clinically backed, natural fat loss ingredient derived from gynostemma pentaphyllum. The patented technology featured in Actiponin® makes it 10 times more potent than traditional gynostemma pentaphyllum extracts. The fundamental mechanism of Actiponin® is the activation of 5′ AMP-activated protein kinase (AMPK) which is typically activated by exercise and plays a crucial role in metabolic health by regulating fat-burning along with energy production.During 12 weeks of Actiponin® supplementation, total abdominal fat area, body weight, body fat mass, percent body fat, and BMI were significantly decreased. In this same study, waist circumference decreased on average 2.90 cm (1.1 inches) over 3 months.</li> </ul> Another recent study showed that 88% of Americans were metabolically unhealthy. Metabolic resistance is a concern for everyone as they try to improve their physical appearance and overall health. Ignite is a unique combination of clinically verified ingredients built to help optimize metabolic health and weight control. Together, these ingredients synergize to reduce the factors which lead to weight gain and insulin sensitivity to create the best metabolic control formulation on the market. </div>

Ignite+ Product Details

BPC+PEA 500

BPC+PEA 500 is a synergistic blend of highly orally bio-available BPC-157 (Arginine Salt) with Palmitoylethanolamide (PEA) and added Salcaprozate sodium (SNAC) for enhanced absorption. This is an ideal formula for anyone looking to support full body repair and regeneration. The peptide BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more. BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders. One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable. We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions. Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy. Palmitoylethanolamide (PEA) is an 18-carbon long- chain fatty acid. Nobel Prize winner Levi-Montalcini identified PEA as a naturally occurring molecule, describing its value in treating chronic infections and pain. Following her discovery, hundreds of scientific studies have been published to show that it is very effective and safe to use. PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system. Its mechanism of action is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs). Palmitoylethanolamide (PEA) is the body’s go-to- molecule and is made on demand when required under disease conditions. This naturally occurs to help resolve inflammation and pain to restore the body to a normal, health state. Due to its ubiquitous nature and presence in all cells, PEA has wide-ranging therapeutic applications. Some of the most common clinical applications are analgesic effects, chronic pain, and inflammation support. PEA has anti-inflammatory effects on the body by inhibiting the production of pro-inflammatory cytokines and by reducing the activity of activated microglia cells. It is also thought to reduce pain by modulating the neurotransmitters involved in pain signaling. In addition to its analgesic and anti-inflammatory effects, PEA is also thought to offer neuroprotection by reducing the levels of reactive oxygen species and by modulating cell death pathways. It has also been shown to improve cognitive function in animal models of Alzheimer's disease. The endocannabinoid system is involved in a wide range of physiological processes, including digestion. The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation. PEA is one of the most abundant endocannabinoids in the gut and is thought to play a key role in gut-brain axis. The endocannabinoid system is known to be involved in various digestive disorders, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Several studies have shown that PEA is effective in reducing symptoms of IBS, such as abdominal pain and bloating. A recent clinical trial showed that a PEA-based product was able to significantly reduce IBS symptoms in patients who did not respond to standard therapy. PEA has also been shown to be effective in supporting other digestive disorders such as GERD and IBD. In a clinical trial, PEA was able to significantly reduce symptoms of GERD, such as heartburn and acid reflux.

BPC+PEA 500 Product Details

BPC-157

BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more. BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders. One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable. We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions. Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy.

BPC-157 Product Details

Glycine Powder

Glycine Powder Product Details

Creatine Monohydrate

Creatine Monohydrate Product Details

Traumeric

Inflammation is a natural part of the body’s immune response; a cascade triggered to protect and maintain normal tissue repair. This non-specific physiological response is part of the innate immune system, a first line of defense that is mediated locally by protective mechanisms that stimulate chemokine and eventually eicosanoid and cytokine production. Traumeric is a natural complex of the entire turmeric root that includes all three curcuminoids, turmerin protein, turmerone oil, β-elemene, curdione, bisacurone and calebin A, making it a comprehensive inflammatory support option that provides broader benefit than isolated curcumin compounds alone. Traumeric contains a standardized amount of 45%–55% curcuminoids, 2%-6% turmerin protein, 3%-8% volatile oils; quercetin, rutin and bromelain that support healthy inflammatory signaling. Traumeric balances prostaglandin, prostacyclin, leukotriene and thromboxane metabolism and inhibits the activating signals of a wide variety of compounds involved in pain and inflammation from exercise. Suggested Use: 2 or more capsules per day or as recommended by your health care professional.

Traumeric Product Details

Liposomal Vitamin C with R-Lipoic Acid

Liposomal Vitamin C with R-Lipoic Acid Product Details