Specialty Applications

Thrivagen

***Female Product Only*** This gentle yet powerful adaptogenic tonic supports a healthy female reproductive and endocrine system, no matter the time of the month. It is designed to help maintain hormonal harmony, balanced moods, sustained energy and restful sleep.* Adaptogenic Botanicals – Adaptogens are botanicals that support the body’s response to daily stressors while boosting health and vitality. These botanicals are shown to address female health concerns exacerbated by tension, including fatigue, menstrual irregularity, and low libido.<a href="https://www.quicksilverscientific.com/pro-resource/">†</a> Monthly Regularity + Resilience – An exclusive blend of 16 herbs crafted by master herbalist Dan Moriarty. These botanicals help maintain menstrual regularity and low levels of menstrual discomfort. Chaste Tree berry is included for its reputed thermoregulatory effects, while Shatavari is known to produce natural phytoestrogens.<a href="https://www.quicksilverscientific.com/pro-resource/">†</a> Unsurpassed Bioavailability – This highly absorbable liposomal adaptogenic tonic offers fast uptake and equal or greater potency than standard dry herbs or tinctures, for results you can feel.<a href="https://www.quicksilverscientific.com/pro-resource/">†</a>

Thrivagen Product Details

The One

The One Product Details

Keto Before 6

<div class="elementor-element elementor-element-65a6861c title elementor-widget elementor-widget-heading" data-id="65a6861c" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">On Demand Ketosis</h2> </div> </div> <div class="elementor-element elementor-element-68be9c01 description elementor-widget elementor-widget-text-editor" data-id="68be9c01" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> Keto Before 6® is an innovative phytonutrient blend that supports critical metabolic pathways and signaling molecules activated by the ketogenic diet. The ingredients in Keto Before 6® activate AMPK, an ancient signaling pathway activated by the keto diet that stimulates energy generation, decreases inflammation, fine-tunes metabolism, and boosts cellular repair mechanisms. mTOR is an anabolic pathway that opposes AMPK activity. Specific nutraceuticals enhance AMPK signaling, amplifying the pathways induced by a keto diet. Our formula is carefully calibrated to help your patients enter ketosis with ease while providing them the flexibility to enjoy carbohydrates at night. The result is a sustainable diet that promotes the benefits of keto without 24/7 dietary deprivation. Resveratrol – Resveratrol stimulates AMPK, inhibits mTOR, and boosts the production of new, healthy mitochondria. It also decreases oxidative stress. Berberine HCL – Berberine HCL activates AMPK and inhibits mTOR to ultimately improve glucose metabolism and enhance insulin sensitivity. Quercetin – Quercetin Dihydrate offers antioxidant effects by increasing AMPK expression. It also stabilizes mast cells, offering anti-inflammatory and antihistamine properties. Milk thistle seed extract – Milk thistle extract activates AMPK and supports liver health, which is essential for realizing the health benefits of a keto diet. DIM – DIM (diindolylmethane) regulates mTOR and balances the immune system. Cinnamon Bark Oil – Cinnamon bark oil activates AMPK, inhibits mTOR, and improves fasting blood sugar and Hemoglobin A1c levels. Traditional oral formulations of resveratrol, berberine, and quercetin have low bioavailability. Keto Before 6® delivers these nutraceuticals in a nanoemulsified system, allowing the body to enter ketosis quickly and efficiently. </div> </div>

Keto Before 6 Product Details

Longevity Elite

<div data-widget_type="heading.default" data-element_type="widget" data-id="65a6861c" class="elementor-element elementor-element-65a6861c title elementor-widget elementor-widget-heading"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">The Ultimate Age Rebel</h2> </div> </div> <div data-widget_type="text-editor.default" data-element_type="widget" data-id="68be9c01" class="elementor-element elementor-element-68be9c01 description elementor-widget elementor-widget-text-editor"> <div class="elementor-widget-container"> Longevity Elite® is our patent-pending harmonious blend of botanicals, phytochemicals, and the hormone precursor pregnenolone, designed to provide maximal support for hormonal balance and longevity. Pregnenolone – Pregnenolone is a vital precursor in the synthesis of the body’s steroid hormones, including cortisol, estrogen, progesterone, testosterone, and DHEA. In addition, it maintains a healthy balance between stress and sex hormones along the HPA axis. Astragaloside IV and Cycloastragenol – Astragaloside IV and Cycloastragenol are two of the most important phytochemicals found in Astragalus membranaceous, a revered botanical in Traditional Chinese Medicine (TCM). These compounds maintain and restore telomere length, inhibiting aging at the DNA level. GS15-4® Fermented Korean Panax Ginseng Extract – Panax ginseng is a foundational tonic in TCM. It induces a mild stress response inside the body, upregulating stress resilience at the cellular level. It also supports nitric oxide production for a healthy cardiovascular system, supports robust levels of the critical longevity hormone DHEA, and supports AMPK, an integral cellular energy sensor intrinsically involved in the aging process. Ginseng Plus® Panax Notoginseng – Panax notoginseng contains phytochemicals called ginsenosides that regulate cellular senescence, a process intrinsic to aging that is associated with an unproductive inflammatory response and declines in immune function, supporting internal environment more conducive to healthy aging. He Shou Wu – He Shou Wu, also known as “tuber fleece flower,” is a revered botanical TCM. It contains polysaccharides and anthraquinone glycosides that modulate the immune system, supporting youthful immune activity. Ashwagandha – Ashwagandha is a strengthening tonic in Indian Ayurvedic medicine, valued for its anti-stress activity. It regulates the HPA axis and heat shock proteins, critical mediators of the stress response involved in aging. Zhi Gan Cao – This honey-prepared licorice formula is used in TCM to tonify Spleen-Qi, which correlates with the digestive system and circulatory system. It harmonizes the effects of the more stimulating herbs in Longevity Elite™, such as Panax ginseng. Licorice is rich in glycyrrhetinic acid, which balances active cortisol with inactivated cortisone, maintaining HPA axis balance from the top down. </div> </div>

Longevity Elite Product Details

Pure DHEA

Pure DHEA Product Details

NanoMojo

NanoMojo Product Details

DHEA+

Nanoformulated DHEA+ Female Hormone Tonic is a balanced blend of micronized DHEA, pregnenolone, diindolylmethane, chrysin, and premium herbal extracts. The targeted formula is designed to help support and balance healthy hormone levels for women in the perimenopausal, menopausal, and post-menopausal stages of life.* <ul class="a-unordered-list a-vertical a-spacing-mini"> <li>Healthy Aging Head to Toe – Natural DHEA production peaks between the ages of 25 and 30. Supplementation of this influential hormone supports healthy energy and muscle maintenance.*</li> <li>Balance for Vital Hormones – Pregnenolone is a precursor to all life-harmonizing stress hormones, and also tied to healthy cognitive function.*</li> <li>Chrysin and DIM support healthy estrogen levels and metabolism, while adaptogenic herbs like ginseng and maca support healthy stress resilience.*</li> </ul>

DHEA+ Product Details

Nanofuel

NanoFuel is a potent, nanoemulsified brain tonic containing a blend of botanical nootropics and compounds that support energy, focus, and productivity. GS15-4® Fermented Korean Panax Ginseng Extract contains ginsenosides that improve glycemic control, enhance nerve growth factor (NGF) expression, and scavenge free radicals in the brain, optimizing neural circuitry. American Ginseng enhances working memory by bolstering choline acetyltransferase, an enzyme involved in acetylcholine neurotransmission. Ginseng Plus® Panax Notoginseng Root Extract supports cerebral blood flow and regulates anxiety and depressive behaviors. Epimedium Sagittatum Extract and LifeFlower® Erigeron Breviscapus Herb Extract improve cerebrovascular circulation, enhancing the delivery of vital oxygen and nutrients to the brain. Bacopa Monnieri Herb Extract supports nitric oxide-mediated vasodilation and attenuates stress-induced changes to brain structures critical for memory and learning. Caffeine Anhydrous and Guarana Seed Extract supply a small amount of caffeine to enhance mental arousal and potentiate memory formation. Theacrine (as Teacrine®) is a non-habit-forming nootropic that enhances focus and concentration while attenuating potential caffeine-induced jitteriness. Dimethylaminoethanol (DMAE), L-Alpha Glycerylphosphorylcholine (GPC), and Phospholipids (from Purified Sunflower Seed Lecithin) provide choline, increasing circulating acetylcholine levels in the central nervous system, supporting acetylcholine-dependent cognitive functions. Ginger oleoresin and cinnamon and clove oils impart our formula with a delicious flavor and act as potent circulation enhancers.

Nanofuel Product Details

Lipocalm

LipoCalm® is an elegant blend of nutraceuticals designed to ease the body into parasympathetic mode, supporting a calm mind and body. PharmaGABA®: PharmaGABA® is a highly-bioavailable form of the neurotransmitter GABA (gamma-aminobutyric acid). GABA interacts with receptors along the gut-brain axis, the essential neural pathway that connects the gut and brain. GABA opposes glutamate, the body’s primary excitatory neurotransmitter, supporting calming neurotransmission. Supplemental GABA has been found to ease anxiety, reduce sleep latency, and enhance the restorative quality of sleep. Skullcap Herb Extract: Skullcap (Scutellaria lateriflora) has been used for centuries in traditional herbal medicine to allay tension and promote sleep. It contains flavonoids that bind with GABA receptors, bolstering calming neurotransmission. Liquid Passionflower Extract: Passionflower (Passiflora incarnata) is a vine with purple and white blossoms traditionally used for sleeplessness and anxiety. It also contains flavonoids that bind GABA receptors. Chamomile Flower Oil: Egyptian blue chamomile (Matricaria chamomilla) contains apigenin, a flavonoid that boosts GABA signaling. Absorption of nutraceuticals can be limited by breakdown in the gastrointestinal tract. Liposomal delivery systems improve the absorption of many nutraceuticals, resulting in higher bioavailability. LipoCalm® delivers calming compounds in nanoscale liposomes, offering rapid support for relaxation and restorative sleep.

Lipocalm Product Details

GABA + L-Theanine

GABA with L-theanine combines a highly-bioavailable form of GABA, the body’s primary inhibitory neurotransmitter, with the green tea-based compound L-theanine. Together, these ingredients provide dynamic parasympathetic nervous system support, helping your patients experience calm and relaxation in our frenetic modern-day world. GABA – GABA (gamma-aminobutyric acid) is produced by neurons throughout the gut-brain axis, the vital neural pathway that links the gut with the central nervous system. GABA is an inhibitory neurotransmitter that calms the sympathetic “fight-or-flight” response and activates the parasympathetic “rest-and-digest” response. Chronic stress depletes GABA, creating a vicious cycle of anxiety and hypervigilance. Supplemental GABA has been found to reduce stress, alleviate anxiety, and improve sleep quality. L-theanine – L-theanine is an amino acid analogue found in high amounts in green tea. It offers potent anti-stress effects without causing drowsiness. It supports a positive mood and boosts levels of the neuroprotective signaling molecule BDNF. Importantly, L-theanine also inhibits excitatory glutamate signaling, which can harm the brain in excess. The bioavailability of GABA and L-theanine is strictly limited in the gastrointestinal tract. Quicksilver Scientific’s advanced liposomal delivery system offers an elegant solution to this problem, significantly enhancing GABA and L-theanine bioavailability for rapid, powerful calming effects.

GABA + L-Theanine Product Details

Ultra Energy

A balanced blend of adaptogenic herbs hand tailored by master herbalist Dan Moriarty of Sun Horse Energy. Packaged in our advanced nano-liposomal delivery system, Ultra Energy helps our bodies respond to high demand with resilience and vigor, not fight, flight or exhaustion.* <ul> <li>Supports vigor and resilience for both men and women*</li> <li>Helps maintain endurance*</li> <li>Contains thirteen unique herbs</li> <li>Quicksilver Delivery Systems® allows full efficacy with a fraction of a standard dose</li> <li>A universal adaptogenic formula that may support adrenal function, and then spreads its action through the entire body. Gentle enough for everyday use.*</li> <li>Herbs are encapsulated in tiny, highly absorbable liposomes. The result is an adaptogenic tonic that offers rapid uptake and equal or greater potency than standard dry herbs or tinctures.*</li> <li>The powerful botanicals in this formula are sourced globally, from Russia, America, South America, Asia and the Indian subcontinent, to create a formula that draws on the best adaptogenic traditions in each region.</li> <li>Each bottle contains 50 400-mg servings.</li> </ul>

Ultra Energy Product Details

NAD+ Platinum

NAD+ Platinum is a blend of NMN, methylation cofactors and sirtuin activators. It combines the action of 3 separate products (NAD Gold, Methyl Charge and The One) to offer the most synergistic and complete longevity formula available. NAD+ Platinum contains nicotinamide mononucleotide (NMN), a stable precursor of the longevity molecule NAD+. NAD+ is found in every cell in the body, which is essential for regulating cellular energy production, mitochondrial function, and sirtuin activation. Quercetin and resveratrol are potent phytochemicals that activate sirtuins, effectively synergizing with NAD+ to support optimal sirtuin activity. Quercetin also has the benefit of acting as a senolytic, selectively neutralizing aging cells. TMG, riboflavin and vitamin B12 help maintain a healthy methylation cycle, a crucial element of cellular NAD+ production.

NAD+ Platinum Product Details

Pure PC

Nourish the very foundation of optimal wellness: the cell. Phosphatidylcholine (PC) helps replenish cell membrane structure and function, supports cognitive sharpness, and helps energize mitochondria (the ‘batteries’ of the cell)* <ul style="font-weight: 400;"> <li>Promote Memory + Focus – PC can be especially effective for supporting cognitive function due to its status as a acetylcholine precursor, a neurotransmitter involved in memory and alertness.†</li> <li>Liver Detox – PC is known to support liver detox, bile movement and toxin flushing. It is also an emulsifier necessary for fat and cholesterol metabolism.†</li> <li>Unsurpassed Absorption – We don’t know of any other PC on the market that can duplicate our exclusive absorption enhancement process. Our direct-access PC is micellized into extremely small droplets that are more easily absorbed into the bloodstream and cell membranes, after ingestion.†</li> <li>Quicksilver Scientific has dramatically enhanced Phosphatidylcholine absorption with advanced liposomal delivery.</li> <li>Most liposomes on the market use low grades of phospholipids, e.g. raw lecithin. Quicksilver Delivery Systems uses smaller, more stable, tightly distributed single-layer spheres that begin absorbing as soon as they hit your mouth.</li> <li>Phosphatidylcholine may replenish cell membranes, help metabolize cholesterol and fat, support cognitive function, and offer liver support.*</li> <li>Each 5 mL of Micellized Pure PC delivers 650mg of phosphatidylcholine.</li> <li>This product does not contain gluten.</li> </ul>

Pure PC Product Details

Membrane Mend

Feed the Brain of Your Cells – High-grade PC and Ahiflower® fatty acid complex sync perfectly to help build and repair membranes. We need this smart barrier to maintain a healthy, energy-producing environment and keep out unwanted molecules, ions, and oxidative threats. Support Cellular Longevity – Potentially harmful inflammatory activity — a hallmark of aging — happens within our cells, too. The powerful antioxidant effects of astaxanthin, vitamin E, and fatty acids in Membrane Mend work fluidly to help balance inflammation at a cellular level. Uncover Energy Potential – The mini energy factories of our cells, mitochondria, have their own biological membranes. Because these powerhouses the energy “currency” used by every cell and tissue in the body, we need mitochondrial membranes to remain intact and functioning well at all times. Every cell and organelle in the human body is encapsulated by a lipid membrane that serves as the initiation point for intracellular signaling pathways. A number of modern-day factors such as toxin exposure, poor diets, and ongoing stress can disrupt the integrity and health of the cell’s membranes. Membrane Mend is a nanoemulsified blend of phosphatidylcholine; a major constituent of all cell membranes, the plant-based essential fatty acid Ahiflower® astaxanthin; and tocotrienols designed to promote the health and resilience of the cell and organelle membranes.

Membrane Mend Product Details

H2 Elite

Hydrogen, one of nature’s purest and gentlest antioxidants, is created by the natural reaction of magnesium with water. This advanced formulation delivers the free radical quenching power of molecular hydrogen to any non-carbonated beverage.* <ul> <li>One of nature’s simplest and most effective antioxidants*</li> <li>Can promote healthy metabolism*</li> <li>Can increases energy*</li> </ul> <ul class="a-unordered-list a-vertical a-spacing-mini"> <li>A groundbreaking formula that infuses pure water with the highest concentration of H2 available that we know of.*</li> <li>One of nature’s simplest and most effective antioxidants, molecular hydrogen can promote healthy metabolism and support energy.</li> <li>Each tablet delivers 80 mg of magnesium malate in a proprietary hydrogen base.</li> <li>Drop one tablet in a cup of pure water (12-16 oz). Wait for the tablet to dissolve. Stir if necessary, and drink immediately. Repeat up to 3 times daily.</li> <li>Does not need a closed container and dissolves in less than two minutes.</li> </ul>

H2 Elite Product Details

CoQ10

CoQ10 (short for coenzyme Q10, also known as ubiquinone) is the only fat-soluble antioxidant our bodies make—found in abundance in all of our fifty trillion cells’ lipid-rich membranes. It is essential to producing ATP, the universal energy currency of our cells. Maintaining adequate levels of CoQ10 is a key part of supporting overall health.* <ul> <li>Protects against oxidative stress*</li> <li>Supports cardiovascular health*</li> <li>Potent antioxidant properties*</li> </ul> <ul class="a-unordered-list a-vertical a-spacing-mini"> <li>Gastrointestinal absorption of CoQ10 is dramatically improved with a nanoemulsified format.*</li> <li>CoQ10 is essential to producing ATP, the universal energy currency of our cells. Maintaining adequate levels of CoQ10 can be a key part of supporting overall health.</li> <li>Each 1 mL of Liposomal CoQ10 delivers 30 mg of CoEnzyme Q10.</li> <li>With the world’s most advanced phospholipid delivery systems, Quicksilver Scientific supplements nourish cells as they deliver their core ingredients faster and more efficiently.</li> <li>This product uses phospholipids from purified sunflower seed lecithin and does not contain gluten.</li> </ul>

CoQ10 Product Details

Thymosin

Thymosin Beta-4-Frag 500+ is a synergistic blend of Acetyl-N-Ser-Asp-Lsy-Pro (AcSDKP), a biologically active fragment of Thymosin Beta-4 (TB-4) and Thymogen (Glu-Trp) which is a bioregulator dipeptide. These orally bioavailable peptides are combined with salcaprozate sodium (SNAC) for enhanced absorption. The fragment featured in this formula has been found to be 10x more potent compared to the full-length TB-4 by weight. Research has confirmed its regenerative potential, immune modulation, supportive role for gut health, inflammaging and fibrosis. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that has been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) nine-fold without affecting tight junctions. Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption without compromising its stability or efficacy.

Thymosin Product Details

Telomere Prime

As the science of longevity continues to evolve, more and more researchers are focusing on geroprotectors- compounds capable to have the potential to prevent or even reverse aging at the cellular level. Telomere Prime reflects cutting-edge science, featuring a broad spectrum of ingredients that have been shown to support healthy cellular function. The health of our cells is foundational to our overall health, so supporting our health and vitality is one of the smartest things we can do for our long-term wellbeing. The compounds in Telomere Prime have been carefully chosen for their ability to protect and repair DNA, reduce telomere shortening and support healthy cellular function. Telomere Prime supports genomic stability and other key indicators of healthspan and lifespan such as, antioxidant protection, body global cell health, inflammation support, and mitochondrial function. Featured Benefits: <ul data-mce-fragment="1"> <li data-mce-fragment="1">Support the body’s natural ability to repair its own DNA. </li> <li data-mce-fragment="1">Significantly increases telomere length in yearlong clinical trials. </li> <li data-mce-fragment="1">Inhibit synthesis of pro-inflammatory “inflammaging” cytokines such as interleukin (IL)-6, (IL)-8, NF-KB and TNF-alpha. </li> <li data-mce-fragment="1">Prevent cell death through inhibition of the pro-apoptotic factors. </li> <li data-mce-fragment="1">Support your DNA’s defenses against free radical damage and activates NRF2</li> <li data-mce-fragment="1">Activates the cell and mitochondrial renewal process</li> <li data-mce-fragment="1">Chelate divalent metal ions. </li> <li data-mce-fragment="1">Protect against damage caused by the prooxidants ferric-NTA and β-amyloid. </li> <li data-mce-fragment="1">Enhance the immune system by increasing the life cycle of white blood cells. </li> <li data-mce-fragment="1">Helps reduce DNA and mitochondrial damage and protect against free radicals. </li> <li data-mce-fragment="1">Protect against UV and gamma radiation by neutralizing radiation-induced reactive oxygen species (ROS). </li> </ul> ac-11® Cat's Claw Aqueous Extract (Uncaria tomentosa) ac-11® is an all-natural, safe, and effective aqueous extract of Uncaria tomentosa, a medicinal plant indigenous to the Amazon rainforest. Manufactured using a proprietary process, this extract provides a broad spectrum of health benefits, primarily directed towards systemic DNA repair, environmental stress, infection, immunosenescence and aging. Scientists have determined that when the body is subjected to external stressors such as overexposure to the Sun (UV radiation), strenuous exercise, pollution, and/or the general effects of aging, our DNA is damaged. Such cumulative DNA damage has been scientifically confirmed as a causative factor in the age-onset disease. In a series of peer-reviewed scientific and clinical studies conducted by third-party laboratories and university medical centers, ac-11® has been proven to help the body’s natural ability to repair its own DNA. The primary active ingredients of ac-11® are formed by the complex molecular chains known as CAEs (Carboxy Alkyl Esters). CAEs are responsible for approximately 90% of ac-11®’s therapeutic benefits. Studies demonstrate that this patented technology: <ul data-mce-fragment="1"> <li data-mce-fragment="1">Increases telomere length in a cell (Patent No.: US 10,098,922B1)</li> <li data-mce-fragment="1">Helps the body’s natural ability to repair its own DNA </li> <li data-mce-fragment="1">Enhances the immune system by increasing the life cycle of white blood cells</li> <li data-mce-fragment="1">Repairs neural function damaged by overexposure to high decibel noise</li> <li data-mce-fragment="1">Helps to normalize the expression of NF-KB, thereby regulating the cellular response to systemic inflammation</li> <li data-mce-fragment="1">Maintains telomere length and integrity during the process of cellular mitosis </li> <li data-mce-fragment="1">Increases production of natural collagen III, a form of collagen associated with soft, supple, youthful-looking skin </li> </ul> ac-11® differs from all other Uncaria tomentosa extracts, most of which are sold under the common name “cat’s claw,” in that its molecular composition is distinct. Such distinction is achieved through an ultra-filtration process that produces a low weight (less than 10,000 Daltons) bioavailable, scientifically indole alkaloid free (less than 0.05 ppm) extract. The inner bark of the plant (Uncaria tomentosa) used to manufacture ac-11® is harvested in the Amazon rainforests of Brazil and Peru utilizing an eco-friendly and renewable process. 2-HOBA (as Hobamine®) Hobamine™, or 2-hydroxybenzylamine (2-HOBA), is a naturally occurring compound in Himalayan Tartary Buckwheat that is at the forefront of new developments to support cellular health, particularly as we age. Hobamine™ (2-HOBA) works by rapidly capturing specific reactive compounds formed by oxidative stress. This capture prevents those compounds from binding to and damaging other cellular components like proteins, lipids, or DNA and impeding normal function of the cell. An NIH-funded study found that Hobamine™ supplementation led to positive changes in 15 inflammatory biomarkers associated with immune system balance in both younger and older adults. Hobamine™ works by scavenging pro-inflammatory reactive lipids, helping maintain immune homeostasis, and supporting your immune system's ability to stay in balance even when exposed to oxidative stressors. Hobamine™ has been shown to promote normal cell function in brain cells, blood vessels, and heart, lung, and immune cells from the effects of oxidative stress, which helps to support healthy function. Hobamine™ is an emerging solution for anyone experiencing the signs of premature aging due to oxidative stress. L-Ergothioneine (as MitoPrime®) Ergothioneine is an amino acid — a building block to proteins — that is synthesized by bacteria and fungi, leading mushrooms to be the primary dietary source. Since its discovery, the unique properties of the, ergothioneine has intrigued researchers for more than a century. Emerging research shows that it is a full spectrum cyto-restorative that protects and repairs the complete cell, including DNA and mitochondria, from the full array of assaults both endogenous and exogenous. Ergothioneine is an antioxidant concentrated in mitochondria, suggesting a specific role in protecting mitochondrial components such as DNA from oxidative damage. Ergothioneine is readily absorbed after oral supplementation, resulting in significant increases in plasma and whole blood ergothioneine levels In one study using cells exposed to oxidative conditions found that ergothioneine treatment significantly lengthened telomeres and reduced the percentage of shortened telomeres after eight weeks. Treating the cells with ergothioneine also boosted the activity of telomerase which is the only enzyme that maintains telomere length. Another recent publication investigated how ergothioneine levels relate to mortality. The looked at levels of 112 compounds in the blood of 3,200 Swedish adults, ergothioneine exhibited the strongest connection with reduced mortality — higher levels of the compound markedly reduced the risk of all-cause mortality, cardiovascular-related mortality, or developing heart disease at all. Due to the recent published research, ergothioneine is being referred to as the ‘longevity vitamin’. Spermidine (as Puremidine®) Spermidine is a polyamine compound found naturally in most living organisms and certain foods. It has been studied for its potential health benefits since the early 1970’s. Spermidine is believed to have anti-aging properties that can protect against cellular damage and enhance cell function. Research has shown that it may improve heart health, increase longevity, and support healthy inflammation levels through the body. Studies have also demonstrated that spermidine can help boost cognitive function and memory by stimulating the release of brain-derived neurotropic factor (BDNF) and increasing the number of synaptic connections in the brain. Another potential benefit of spermidine is its ability to reduce oxidative stress and improve mitochondrial function. Spermidine has been shown to help protect our cells from damage of aging, which leads to a host of age-related disease. Research has shown that when spermidine is supplemented, it can help lengthen telomeres and restore their protective effects. It also helps improve cell metabolism, which can result in increased energy production and better overall health. Sulforaphane Glucosinolate (as Activated BroccoRaphanin®) Sulforaphane is a type of isothicyanate and a metabolite of glucoraphanin which is a phytonutrient found in cruciferous vegetables, such as broccoli, brussels sprouts, and cabbage. Studies have suggested that consumption of sulforaphane can provide numerous health benefits, such has reducing oxidative stress and supporting inflammation levels. In addition to its potential therapeutic effects sulforaphane has been studies for its ability to enhance the body’s natural defense mechanisms. It has been shown to activate enzymes that help protect cells and DNA from damage. Studies have also suggested that sulforaphane may play a role in enhancing the body’s natural detoxification process, helping to flush out harmful toxins from cells. The myrosinase enzyme added into Telomere Prime is necessary for the conversion of glucoaphanin to sulforaphane. The enzyme is released by the plant upon chewing or chopping and is responsible for activating sulforaphane. Buckwheat Peptides The protein isolated from buckwheat have been hydrolyzed into a range of peptides. These peptides showed diverse biological activities in vitro and in vivo. They include trypsin inhibition, anti-aging, modulating gut microbiota, heart, and immune support. Telomere Prime showcases the latest advancements in healthy aging support and features ac-11 Cat’s Claw, 2-hoba, L-ergothioneine, spermidine, sulforaphane with myrosinase and buckwheat peptides. It is the perfect way to give your cells the boost they need to stay health and support your overall health as you age. So, if you are looking for a natural way to support your longevity, Telomere Prime is part of your solution.

Telomere Prime Product Details

Resolve+

Aging is characterized by an increase in the concentration of inflammatory markers in the blood- stream, a phenomenon that has been termed “inflammaging”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low-grade inflammation is likely to be detrimental for many tissues and for normal functions. Our team investigated various natural solutions targeting multiple influences of inflammaging. Resolve+ contains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms. Acmella oleracea (“jambu”) is sourced from Sardinia, Italy and rich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth. Acmella oleracea has been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides and cannabinoid type 2 (CB2) activation. There are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of Acmella. Studies reported in this review confirmed activities of Acmella, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α. Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L.), has been well documented to exhibit various health benefits. There have been many claims on the health benefits of curcumin on neurological, cardiovascular, lung, metabolic, and liver function, mainly through its anti-inflammatory and antioxidant properties. Despite its promising potential, the clinical application of curcumin has been limited due to its low bioavailability. To enhance curcumin absorption, we are the first to feature Theracurmin Super® 85X, a proprietary curcumin utilizing the latest technology that transforms standard curcumin into an amorphous structure. Theracurmin Super® 85X uses the latest technology to transform regular curcumin particles into a more bioavailable structure. This is done by splitting curcumin particles’ crystal structure amorphous, therefore, making it easily absorbed and bioavailable to maximize its supportive potential. Tetrahydrocurcumin (4-HC) is the key bioactive derivative of curcumin, it’s also given credibility as the engine behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that 4-HC attenuated pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-⍺, and prostaglandin E2. After reviewing the data, we found many advantages to infuse tetrahydrocurcumin as CurcuPrime® stacked with Theracurmin Super® 85X into Resolve+. Quercetin is a well-known studied dietary flavonoid ubiquitously present in various vegetables. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production. Multiple studies have confirmed its supportive potential as an immune modulator and its ability to support a healthy inflammatory response. It can improve the Th1/Th2 balance, and restrain antigen specific IgE antibody formation However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology which we feature in resolve is the preferred delivery system to overcome these limitations. This enhanced form of quercetin has been shown to be as much as 20 times better absorbed than other quercetin options. Casperome® boswellia phytosome is a potent extract made from the resin of Boswellia serrata trees and is also referred as Indian frankincense. Boswellia extracts have been demonstrated to be effective in the management of various inflammatory response functions including those that occur in the bowel, joints, bones, respiratory airways and in the brain. The mechanism of action that involves the modulation of the natural inflammatory response both acting on prostanoid synthesis (mPGE2S) and protein degradation (caspases), and transcription factors (Nf-κB). We have selected Casperome® which is a highly standardized in boswellic acids to match the natural composition of boswellia, formulated with phytosome technology to achieve optimized absorption and has been validated by over 10 human studies. Perilla frutescens is an annual herb belonging to the mint family (Lamiaceae). It is mainly produced in countries like China, Japan, India, Thailand and Korea. Recently, Perilla is gaining more attention because of its medicinal benefits and phytochemical contents. The functional compounds of Perilla Seed Extract are flavonoid Aglycons – polyphenols such as Luteolin, Apigenin, Chrysoeriol, and Rosemarinic Acid. Studies have shown that Perilla seed polyphenols regulate allergic and inflammatory response due to its 5-lipoxygenase inhibitory activity and suppression potential of histamine release from mast cells. AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has been shown to provide full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a health. AstraGin® has been shown in numerous studies to increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. Additionally, AstraGin® was shown to reduce intestinal inflammatory biomarker MPO, the pro-inflammatory cytokines IL-6, IL-17, and IL-1β in ulcerative colitis patients.

Resolve+ Product Details

Rejuvenate (Senolytic)

Cellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses. This has numerous implications for the body, including its ability to adapt to changes in its environment, as well as its capacity to regenerate itself. This can be beneficial for individuals to understand how cellular senescence works and what the potential benefits are for the body. Firstly, understanding cellular senescence can help us better understand aging, as this process is a major contributor to the aging process. Additionally, it can also provide insight into certain diseases and conditions that may be linked to the inability of cells to divide and proliferate properly. Finally, by targeting cellular senescence, we may be able to find new ways of fighting against aging and diseases associated with it. Thus, understanding ways to best support cellular senescence can be a powerful tool in our pursuit of longevity and improved health span. Senolytics, are small molecules that can selectively kill senescence cells and have been developed to support various age-related diseases while also extending healthspan. In recent years, emerging natural compounds have been discovered to be effective senolytic agents that are featured in this breakthrough formula. Clearance of senescent cells can support the reduction of inflammation, decrease macromolecular dysregulation, and enhance function of stem and progenitor cells. Rejuvenate presents a unique solution for intervention through two mechanisms: (1) eliminating senescent cells (senolytics) (2) inhibiting of senescent- associated secretory phenotype (SASP) Featured benefits: <ul data-mce-fragment="1"> <li style="font-weight: 400;" data-mce-fragment="1">Once weekly pulsed high dosing blend of senolytics which have been shown to reduce senescent cells in vivo.</li> <li style="font-weight: 400;" data-mce-fragment="1">Targets aging at the cellular level</li> <li style="font-weight: 400;" data-mce-fragment="1">Induces autophagy to promote intracellular recycling and cellular renewal</li> <li style="font-weight: 400;" data-mce-fragment="1">Reduce full body features of Senescence-Associated Secretory Phenotype (SASP).</li> <li style="font-weight: 400;" data-mce-fragment="1">Protects cells against free radicals and oxidative stress </li> <li style="font-weight: 400;" data-mce-fragment="1">Targets inflammaging at the cellular level and supports a healthy inflammatory response</li> <li style="font-weight: 400;" data-mce-fragment="1">Supports a healthy immune system </li> <li style="font-weight: 400;" data-mce-fragment="1">Formula designed to also treat muscle senescence.</li> <li style="font-weight: 400;" data-mce-fragment="1">Exercises muscles longer and harder with a boost in citrate synthase activity.</li> <li style="font-weight: 400;" data-mce-fragment="1">Recovers more effectively with a reduction in inflammation biomarkers.</li> <li style="font-weight: 400;" data-mce-fragment="1">Decreases SA-β-Gal by 63% in muscle tissue.</li> </ul> Fisetin: Fisetin is a polyphenol found in many fruits and vegetables, including strawberries, apples, and onions. It has been studied for its potential benefits related to aging. Fisetin has shown great promise to inhibit senescence due to its ability to act on numerous biological processes. Studies have shown that fisetin is the most natural senolytic agent that can protect cells from oxidative damage, protecting them against age related diseases and reduce senescence markers in multiple tissues. Quercetin Phytosome: Quercetin is one of the most studied dietary flavonoids ubiquitously present in various vegetables. A key feature of quercetin is its strong antioxidant activity which potentially enables it to quench free radicals from forming resonance-stabilized phenoxyl radicals. However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology is the preferred delivery system to overcome these limitations. This enhanced form of quercetin has been shown to be 20 times better absorbed than other quercetin options. Spermidine: Spermidine has emerged as an important metabolite that links cellular aging and autophagy. Spermidine is a naturally occurring polyamine involved in biological processes such as cell growth and proliferation, tissue regeneration and translation regulation, making it a critical regulator of cellular homeostasis. Spermidine also exhibits anti-inflammatory and anti-aging properties. External supplementation of spermidine improves longevity, which may be attributed to its ability to exert cardioprotective and neuroprotective effects, as well as reducing immune senescence. Senactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) extracts containing ginsenoside Rg1: Senactiv® promotes more energy and muscle preservation by activating phagocytic macrophages in association with the senescent cell clearance in muscle tissue after aerobic exercise. It's composed of two highly purified and fractionated extracts from Panax notoginseng and Rosa rugosa. Research suggests that this combination is a potent senolytic. Muscle samples taken before and after exercise shows that Senactiv® supplementation resulted in significantly fewer amounts of detectable β-galactosidase-tagged cells which is a method to assess cellular senescence. In a recent Senactiv® human clinical study confirmed, though exercise generally increases the movement of white blood cells and “clean up” cells into the muscle, it does not always activate phagocytosis to clear away the broken down apoptotic cells and senescent cells . With Senactiv®, phagocytosis activation can clear these types of cells away leading to the decrease in both apoptotic and senescent cells in active muscles. TurmiPure GOLD® Turmeric (Curcuma longa L.) has been used in India for more than 5,000 years as a spice and medicinal herb in traditional ayurvedic medicine. Well-known for its anti-inflammatory properties, it is now recognized as the #1 botanical for healthy aging. However, its poor bioavailability (number of actives reaching the blood stream) in curcuminoids lowers its efficacy and its poor solubility limits its application (often limited to capsules and tablets), therefore high intake (~1500mg) of standard turmeric extract was shown to be efficient. After 5 years of research, our partner has overcome these issues by developing TurmiPure GOLD®, the world’s first bioequivalent turmeric at a low dose of 300mg. Its innovative formulation highly enhances the bioavailability of curcuminoids 24X, in addition to being instantly water dispersible. A dose of 300mg of TurmiPure Gold® delivers as many curcuminoids in blood as 1922mg of standard turmeric 95% curcuminoids (with or without addition of 1% black pepper extract standardized to 95% piperine). Curcuminoids are clinically proven to be effective in more than 100 studies to support: healthy joint function (including inflammatory response), normal bile production and overall body function, contributing to healthy aging conditions. Curcumin has shown promise to mitigate the senescence-associated secretory phenotype (SASP) and its aging-induction consequences of senescent cells. Tetrahydrocurcumin (CurcuPrime®) Tetrahydrocurcumin (4-HC) is the key bioactive derivative of curcumin and with advances in science, it’s also given credibility as the engine behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that 4-HC attenuated pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-⍺, and prostaglandin E2. Apigenin: Apigenin is a natural bioactive plant polyphenol with antioxidant, anti-inflammatory and immune system boosting properties. It also helps to support against oxidative stress for better cellular function. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels. Apigenin is known to induce apoptosis in a p53-independent pathway by enhancing oxidative stress. The p53-independent apoptotic effects of apigenin would support its use as a senolytic Luteolin: Luteolin is a flavonoid naturally found in plants. Flavonoids like luteolin have been found to have beneficial effects on human health by reducing oxidative stress. Luteolin, which acts as the first-line defense system in plants against adverse photobiological effects such as protection against UV radiation, has shown promising senotherapeutic effects Green Tea containing epigallocatechin gallate (EGCG) The phytochemical epigallocatechin gallate (EGCG) is the major catechin found in green tea, with many potential benefits on health outcomes, including cell senescence, aging, and age-related diseases. Preclinical evidence suggests that EGCG exhibits promising senolytic and senomorphic effects through multi-faceted mechanisms, including targeting apoptotic pathways, cell cycle regulation, nutrient sensing pathways, SASP, and oxi-inflammatory stress pathways. AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1: AstraGin® is a proprietary plant derived compound complex extracted by a proprietary pharmaceutical extraction and processing technology. AstraGin® upregulates mRNA and protein expression levels of nutrient transporters that regulate the absorption of nutrients and plant compounds in the gut. AstraGin® has shown in 16 in-vitro and 8 in-vivo studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to: <ul data-mce-fragment="1"> <li style="font-weight: 400;" data-mce-fragment="1"> Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. One example is AstraGin® has been shown to increase curcumin absorption by 92%. </li> <li style="font-weight: 400;" data-mce-fragment="1">Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS- induced colitis rats. </li> <li style="font-weight: 400;" data-mce-fragment="1">May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate. </li> <li style="font-weight: 400;" data-mce-fragment="1">May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut- associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages. </li> </ul>

Rejuvenate (Senolytic) Product Details

Primetime

Prime Time is a comprehensive blend of 12 key natural ingredients shown to have a role in supporting age management powered by industry leading 10mg's of spermidine per serving. Prime Time has been formulated with ingredients to mimic fasting and catalyze your body’s natural ability to rid itself of aged cells. Various publications demonstrate the potential this formula will have in your longevity protocols as Prime Time was formulated to support: <ul data-mce-fragment="1"> <li style="font-weight: 400;" data-mce-fragment="1">Epigenetic aging* </li> <li style="font-weight: 400;" data-mce-fragment="1">Boosting autophagy and promote cellular renewal* </li> <li style="font-weight: 400;" data-mce-fragment="1">Fasting*</li> <li style="font-weight: 400;" data-mce-fragment="1">Memory, cognition, and brain health*</li> <li style="font-weight: 400;" data-mce-fragment="1">Cardiovascular health*</li> <li style="font-weight: 400;" data-mce-fragment="1">Beauty from within*</li> <li style="font-weight: 400;" data-mce-fragment="1">Mitochondria* </li> </ul> <header class="section-header"> <h1 class="section-header__title"><a href="https://healthgev.com/pages/what-makes-prime-time-so-impactful">WHAT MAKES PRIME TIME SO IMPACTFUL?</a></h1> </header> <div class="rte rte--nomargin"> Spermidine Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan. The concentration of spermidine declines with age, and exogenous spermidine supplementation reverses age- associated adverse changes and supports health span. Given that it interacts with various molecules, spermidine influences aging through diverse mechanisms. Autophagy is the body's way of cleaning out damaged cells, to regenerate newer, healthier cells and is the main mechanism of spermidine. In addition, spermidine exerts its effects through other mechanisms, including anti-inflammation, histone acetylation reduction, lipid metabolism and regulation of cell growth and signaling pathways. Nicotinamide mononucleotide Nicotinamide mononucleotide, a naturally occurring molecule present in all species. NMN is rapidly absorbed and converted to NAD+, which evidence shows declines as we age. In numerous studies, supplementation has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, and improves neuronal function in the brain among much more. Epigallocatechin-3-gallate (EGCG) Epigallocatechin-3-gallate (EGCG) is the major catechin in green tea. There is consistency in the literature about the beneficial role of green tea on senescence-related mechanisms, thanks to its scavenging properties against reactive oxygen species (ROS) and reactive nitrogen species (RNS) and its ability to stimulate autophagy Alpha-ketoglutarate (AKG) Alpha-ketoglutarate (AKG) is a molecule involved in several metabolic and cellular pathways that declines with age. It works as an energy donor, a precursor in amino acid production, and a cellular signaling molecule, and it is a regulator of epigenetic processes. Dihydroquercetin (Taxifolin) Dihydroquercetin is a powerful antioxidant of plant origin that can protect cells from the harmful effects of free radicals and protect cell membranes against damage Apigenin Apigenin is a natural bioactive plant polyphenol with antioxidant, anti-inflammatory and immune system boosting properties. It also helps to support against oxidative stress for better cellular function. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels. Luteolin Luteolin is a flavonoid naturally found in plants. Flavonoids like luteolin have been found to have beneficial effects on human health by reducing oxidative stress. Trimethylglycine (TMG) Trimethylglycine (TMG) is an amino acid derivative that occurs in plants and has been shown to support methylation which, in turn, supports the homocysteine levels. Taking TMG along with NMN provides the ideal balance for NAD+ production in the body. Resveratrol Resveratrol is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions.The anti-aging mechanisms of resveratrol are mainly modulating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol is considered for the prevention and support of aging and age-related diseases as it mimics the effects of calorie restriction. Pterostilbene Pterostilbene is a phenolic compound in the same family as resveratrol and is present in small amounts in a large variety of foods and beverages like blueberries or red wine. Multiple studies confirm pterostilbene's remarkable anti-aging effects. Cell and animal studies have shown that pterostilbene can extend the lifespan of various animal models of human longevity by regulating three major pathways linked to longevity: mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and sirtuins Bergamot Bergamot (Citrus bergamia) is a type of citrus fruit native to Italy. It has been shown that bergamot juice exerts antioxidant, cardioprotective properties and antisenescence effects. AstraGin® AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous. AstraGin® increases the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up-regulating absorption-specific m RNA and transporters such as SGLT1, CAT1, and GLUT4. </div>

Primetime Product Details

Mindset

The powerful combination of TeaCrine®, Dynamine®, RhodioPrime 6x®, InnovaTea®, Asian ginseng and huperzine A help to increase energy levels, cognitive function, motivation, and focus all while reducing fatigue. Mindset may also aid in the prevention of age-related cognitive decline and has neuroprotective properties without the jitters or crash. We have now discovered certain ingredients included in Mindset that have shown positive changes in brain wave activity specifically delta and theta waves which are associated with focus and decision making under pressure. Mindset also features the enhancement of caffeine (increased half-life), and the activation of dopamine receptors are some of the mechanisms by which the ingredients are working, making it the ideal formula to utilize whenever needing a desired edge. TeaCrine® is a trademarked form of a purine alkaloid extracted from kucha tea leaves, called theacrine. Several studies show that TeaCrine® is effective at increasing energy levels, mood, physical performance, and cognitive function. Dynamine® is methylliberine, a derivative of caffeine and relative of theacrine and is faster-acting, harder-hitting in its ability to increase mental energy, alertness and focus. Dynamine® and TeaCrine® both serve a methylurates, a rare class of bioactive ingredients that are neuro-activating yet does not affect heart rate, blood pressure, or vasoconstriction (pressor response). So, they stimulate the Central Nervous System, but not the cardiovascular system. InnovaTea® High Purity Natural Caffeine is a unique, naturally derived source of caffeine extracted from fermented Camellia sinensis (tea leaves). The tea leaves used to produce InnovaTea® are grown by farmers who utilize sustainable farming practices to help reduce environmental impact. The leaves are also fully traceable back to the farms where they are grown. InnovaTea® is an excellent, clean label alternative to chemically synthesized caffeine. Ground-breaking research showed “C3X” (caffeine + Dynamine® + TeaCrine®) boosts caffeine’s half-life 300%, so your energy, mood and focus last 300% longer. When dosing Dynamine® and TeaCrine® alongside caffeine, you can get a much longer-lasting energy boost (3x) than you would using the same amount of caffeine alone. Dynamine® and TeaCrine® activate delta and theta brain waves, which are associated with focus and decision making under pressure. Dynamine® and TeaCrine® also active dopamine receptors, help preserve dopaminergic neurons, extend the half-life of caffeine, and do so without the crash or jitters that can come from caffeine-alone. RhodioPrime 6X® is rhodiola which features a market-leading high 6% salidroside extract, which is 6X the potency of the majority of other rhodiola's on the market. Salidroside is the most bioactive constituent in rhodiola and thought to be responsible for its health-promoting effects. As an adaptogen, rhodiola helps the body resist biological stress. Since stress impacts everything, rhodiola can yield many benefits, such as enhanced mood, endurance, energy, and cognitive function. Studies show that salidroside has various biological effects, providing support for the cardiovascular system, nervous system, liver, and cognition. Its supportive benefits also include providing support for a healthy mood and feelings of well-being, healthy antioxidant status, healthy circulation and oxygenation, anti-aging and vibrant energy levels. Mindset is all about the energy and performance when you need it most. TeaCrine®, Dynamine® and RhodioPrime 6x have all been shown to improve focus and mental clarity, while InnovaTea® has been shown to increase energy levels and reduce fatigue. Asian ginseng and huperzine A help support healthy brain function and cognitive performance.

Mindset Product Details

Longevity

Biological aging is directly impacted by physiological integrity. Muscle strength, mass, function, quantity, and quality loss are some of the main issues associated with the process of aging. As we age the performance of our muscle cells decline which leads to a weakened immune system, sarcopenia, obesity, and chronic disease among much more. Healthgevity has selected PeptiStrong™, Senactiv® and AstraGin® which are all clinically proven ingredients to put your muscles in the best position to thrive regardless of your age. In a recent study it was concluded that lower muscle strength in late adolescence showed direct connection with higher risk of chronic disease. As such, skeletal muscle might be the central integrator between sarcopenia, obesity, immune senescence and more in an aging biological system. Preserving muscle mass is critical for optimizing health span. Research shows the strongest one-third of the population over the age of 60 has a 50% lower death rate than the weakest, making muscle a key predictor of longevity. Recent discoveries of clinically proven ‘growth promoting’ ingredients have made the process of building and preserving muscle more obtainable. PeptiStrong™, Senactiv® and AstraGin® work synergistically to target multiple mechanisms, to provide a wide range of benefits in muscle health. PeptiStrong™ (Peptides from hydrolyzed fava bean protein) Through cutting edge Al-precision technology, Nuritas is creating a brand-new category of precision peptide ingredients from nature. Their cell-signaling power helps the body function at its best. Longevity is the first product resulting from Healthgevity's collaboration with Nuritas and contains PeptiStrong™ : precision peptides that have been clinically proven to support muscle health. PeptiStrong™ can increase muscle synthesis by supporting mTOR, reduce muscle loss by downregulating muscle atrophy related genes and improve muscle health by reducing inflammation properties. Backed by two peer-reviewed clinical studies, this plant-based intelligent ingredient has outperformed animal protein. It has a multi-dimensional effect on muscle health: promoting muscle strength, improving recovery after intense exercise, boosting energy, and supporting the synthesis of protein that assists in maintaining and building muscle. A 'peptide-specific’ effect to address the muscle homeostasis between muscle protein synthesis, muscle atrophy and inflammation, offers an alternative to a purely uncharacterized nutritional intervention. In the most recent double blind placebo clinical study, PeptiStrong™ alone provided: Featured PeptiStrong™ research benefits: <ul> <li>Regenerates muscles by increasing the expression of new muscle fibers.</li> <ul> <li>Type I “Slow Twitch” Muscle Fibers are responsible for endurance and strength endurance. They contain a higher number of mitochondria and utilize fat for energy.</li> <li> Type II “Fast Twitch” Muscle fibers are responsible for strength and force production. Loss of Type II fibers is most associated with aging. </li> </ul> <li>Reduces muscle loss and fat accumulation</li> <li> Reduces Tumor Necrosis Factor-alpha (TNF-α) </li> <li>Improves cellular metabolism through the activation of AMPK which in turn increases the levels of NAD+ and sirtuins</li> <li>Maintains autophagy in skeletal muscle similar to fasting</li> <li>Induces mitochondrial biogenesis in the muscle cell</li> </ul> <div><img src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/Screenshot2023-02-09at9.28.50AM_1024x1024.png?v=1675952967"></div> Senactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) extracts containing ginsenoside Rg1: Senactiv® has over 10 years of research behind it including 2 in vivo studies and 5 human clinical trials. A recent study confirmed a process to reverse aging in muscle cells. Aging in muscle cells is a function of a cell itself, not being able to divide and repair itself. The process is known as cellular senescence, and it happens during aging. This study found that by the overexpression of a particular protein called NANOG, the cell does not have be reset to a different state to reverse aging. Ginsenoside Rg1 contained in Senactiv®, has the potential to activate expression of NANOG to help in reversing the aging process in skeletal muscle. A new mechanism of aging has been uncovered by researchers: the accumulation of sphingolipids. Ceramides, a widely known class of sphingolipids, build up in aging muscle and reduce its function, impacting the functional capacity of older adults. Senactiv® has the potential to inhibit sphingolipid synthesis prevent age-related decline in muscle mass and reduce its function. Senactiv® has been also shown to have the potential to: <ul> <li>Increase endurance performance</li> </ul> <ul> <ul> <ul> <li>endurance performance was extended by increasing energy in cells and increasing glycogen replenishment in muscles</li> </ul> </ul> </ul> <ul> <li>Speed up muscle fatigue recovery</li> </ul> <ul> <ul> <ul> <li>speeding up muscle fatigue recovery can be achieved by decreasing muscle inflammation during exercise and accelerating muscle inflammation recovery after exercise</li> </ul> </ul> </ul> <ul> <li>Muscle regeneration</li> </ul> <ul> <ul> <ul> <li>muscle regeneration was increased by eliminating senescent cells and increasing new muscle growth</li> </ul> </ul> </ul> AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1: AstraGin® has been shown to increase intestinal arginine and leucine absorption by 67% and 58%, respectively, which contributes to the activation of the mTOR pathway and suggest increasing the skeletal muscle protein synthesis by up to 30%. Recent studies show that the gut-muscle axis is a physiological target for combatting anabolic resistance and reducing risk of sarcopenia. AstraGin® has shown in 16 in-vitro and 8 in-vivo studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to: <ul> <li>Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. </li> <li>Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS- induced colitis rats. </li> <li>May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate. </li> <li>May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut- associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages. </li> </ul>

Longevity Product Details

KPV + PEA

Discover the power of KPV (Lysine-Proline-Valine) and Palmitoylethanolamide (PEA) in our advanced formulation, enriched with Salcaprozate sodium (SNAC) for superior absorption. As a potent tripeptide, KPV, sourced from the hormone alpha-melanocyte-stimulating hormone (alpha-MSH), stands out for its remarkable anti-inflammatory potential. In the world of bioactive peptides, KPV has become a focal point for researchers exploring its supportive health benefits and is also referred to as a natural antimicrobial peptide. The synergy of KPV with PEA, an endocannabinoid-like lipid mediator, offers a comprehensive approach often used to support inflammation, gut health, and conditions such as Inflammatory Bowel Disease (IBD). PEA's documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory, and neuroprotective effects make it a versatile ingredient with broad therapeutic applications. Notably, our formulation incorporates SNAC, a cutting-edge intestinal permeation enhancer tested in clinical trials for oral macromolecule delivery. In a groundbreaking study, SNAC demonstrated a remarkable nine-fold increase in peptide absorption without impacting tight junctions. This innovation underscores our commitment to maximizing the bioavailability of KPV and PEA for optimal effectiveness.

KPV + PEA Product Details

Ignite+

Ignite+ is an exclusive breakthrough formula combining the leading ingredients available to increase metabolism, improve insulin signaling, body composition, reduce uptake of glucose into our bodies, and so much more. One of the best ways to prevent insulin resistance is to help remove excess glucose from our blood. We are the first to pair these several effective glucose disposal agents together to target several vital pathways that regulate metabolic efficiency. Ignite+ is an advanced metabolic optimization formula whose ingredients have been shown to support: <ul> <li>Reduction of adiposity and visceral fat*</li> <li>Increase thermogenesis by raising the metabolic rate and calorie burning*</li> <li>Browning of white adipose tissue*</li> <li>Diet-induced weight gain*</li> <li>Increase fatty acid oxidation*</li> <li>Ramp up ketone levels*</li> <li>Improves glucose tolerance and glucose control*</li> <li>AMPK activation*</li> <li>Leptin and ghrelin levels*</li> <li>Regulation of a healthy metabolism and mitochondrial health*</li> </ul> <header class="section-header"> <h1 class="section-header__title"><a href="https://healthgev.com/pages/what-makes-ignite-so-impactful">WHAT MAKES IGNITE+ SO IMPACTFUL?</a></h1> </header> <div class="rte rte--nomargin"> First, we have included InnoSlim®, a proprietary blend of purified, fractionated extracts of Panax notoginseng and Astragalus root produced by a pharmaceutical-grade extraction technology which delivers astragalosides and ginsenosides Rg1 and Rb1. Research has shown it supports the production of adiponectin, a protein hormone that helps modulate metabolic processes such as glucose regulation and fatty acid metabolism. InnoSlim® reduces glucose absorption in the intestine by 42%. This means that only 58% of the glucose you eat will be absorbed in your intestine. In addition, InnoSlim® also increases glucose absorption in muscle and fat cells by 50% and 68% by upregulating GLUT4 transporters, which takes glucose from our blood and transfers it into the muscle tissue. InnoSlim® has also been shown to support appetite control, AMPK activation, insulin resistance, triglycerides and sdLDL in cell, animal and human studies. One other mechanism Ignite targets to improve our metabolic health and weight is to increase the energy expenditure of our bodies. Ignite delivers several ingredients in the formula which help our bodies do this process. Each of these has unique mechanisms of action but combine to make massive differences in the energy we use and how we process glucose in our bloodstream. <ul> <li> MitoBurn® (L-BAIBA): Mitoburn® is an exercise mimetic, which mimics exercise’s effect on our tissues. This signals the body to help reduce fatty acids in our system, which are another energy source other than glucose. It can also help produce ketones which reduce appetite and improve energy output. It has also been shown to: Assist in the browning of white fat, activating AMPK, increasing metabolic rate, supporting leptin levels, and insulin resistance.</li> <li> GlucoVantage® Dihydroberberine: Dihydroberberine is a new version of traditional berberine that is up to 5x more bioavailable/absorbable and 2x longer lasting (8 hours vs. 4 hours). In one study, this led to 25.9% reduced blood glucose levels compared to the start of the trial in many patients. Dihydroberberine can also help with advanced glycation end products correlated with aging while supporting blood glucose disposal and improving insulin sensitivity and body composition.</li> <li> <div> DNF-10 satiety peptide complex is obtained from a screening of small molecular weight peptides (<10 kDa) after proteolysis of Saccharomyces cerevisiae, a non-pathogenic yeast. The peptides from DNF-10 lower the hypothalamic expression of neuropeptide Y and downregulate ghrelin, thereby reducing the physiological hunger cues confirmed in multiple published studies. </div> </li> <li> CalorieBurn GP® Grains of Paradise seed extract (6-Paradol 12.5%): CalorieBurn® contains bioactive compounds 6-paradol, 6-shogaol, 6-gingerol, and 6- gingerdione. These have been shown to effectively trigger highly thermogenic Brown Adipose Tissue (BAT) when taken in a precise ratio to one another, resulting in a 5X increase in calories burned over 2 hours compared to placebo. On average, burned 97 kcal more calories daily and lost more visceral fat. In another study, 40mg results in a 400% increase in metabolic rate within 30 minutes. Administration of this also reverses the unbalanced gut microbiota composition induced by a high-fat diet with a decrease in Firmicutes / Bacteroidetes ratio and increase in general Bifidobacterium and Akkermansia. </li> <li> Factor21® (Bitter Melon Extract): Factor21® is a natural regulator of a hormone growth factor called Fibroblast Growth Factor 21 (FGF21) and is an AMPK activator. FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses. Recent studies have revealed that supporting FGF21 can alleviate many age-related metabolic disorders. Factor21® is also an exercise mimetic that has many actions, including improved insulin secretion to drive glucose out of the bloodstream and inhibit fat cell growth.</li> <li> Actiponin® (gynostemma pentaphyllum extract): Actiponin® is a patented, clinically backed, natural fat loss ingredient derived from gynostemma pentaphyllum. The patented technology featured in Actiponin® makes it 10 times more potent than traditional gynostemma pentaphyllum extracts. The fundamental mechanism of Actiponin® is the activation of 5′ AMP-activated protein kinase (AMPK) which is typically activated by exercise and plays a crucial role in metabolic health by regulating fat-burning along with energy production.During 12 weeks of Actiponin® supplementation, total abdominal fat area, body weight, body fat mass, percent body fat, and BMI were significantly decreased. In this same study, waist circumference decreased on average 2.90 cm (1.1 inches) over 3 months.</li> </ul> Another recent study showed that 88% of Americans were metabolically unhealthy. Metabolic resistance is a concern for everyone as they try to improve their physical appearance and overall health. Ignite is a unique combination of clinically verified ingredients built to help optimize metabolic health and weight control. Together, these ingredients synergize to reduce the factors which lead to weight gain and insulin sensitivity to create the best metabolic control formulation on the market. </div>

Ignite+ Product Details

Cardio NAD+

Vascular health and aging are the most important health care problem in the world today. Healthy aging requires healthy arteries and a healthy heart. Cardio NAD+ is a state-of-the-art solution which uses the most novel ingredients available to help optimize cardiovascular health. As one of the most important systems in your body, we have designed this combination to be synergistic to the many different areas of cardiovascular health while demonstrating cardioprotective effects including the emerging connection between NAD+ and heart health. Featured Supportive Benefits: <ul data-mce-fragment="1"> <li data-mce-fragment="1" style="font-weight: 400;">Improves net NAD+ status by supporting both its synthesis and limiting its degradation </li> <li data-mce-fragment="1" style="font-weight: 400;">Supports healthy blood pressure </li> <li data-mce-fragment="1" style="font-weight: 400;">Improves vascular aging and endothelial function</li> <li data-mce-fragment="1" style="font-weight: 400;">Supports healthy fibrinolytic activity and clotting function</li> <li data-mce-fragment="1" style="font-weight: 400;"> Promotes healthy circulation and blood flow </li> <li data-mce-fragment="1" style="font-weight: 400;">Inhibits platelet & red blood cell aggregation</li> <li data-mce-fragment="1" style="font-weight: 400;">Decreases blood viscosity</li> <li data-mce-fragment="1" style="font-weight: 400;">Supports clinical measures of inflammation </li> <li data-mce-fragment="1" style="font-weight: 400;">Supports healthy blood sugar and insulin levels</li> <li data-mce-fragment="1" style="font-weight: 400;">Inhibits lipid peroxidation</li> <li data-mce-fragment="1" style="font-weight: 400;">Supports healthy lipid metabolism</li> <li data-mce-fragment="1" style="font-weight: 400;">Demonstrated reduction in various independent cardiovascular risk factors</li> </ul> First, we have also included NAD3®, a new and novel ingredient which uses a different approach to manage cardiovascular factors while having positive influences on the hallmarks of aging. NAD3® is a unique blend of Wasabi japonica extract, theacrine and copper(I)-niacin complex. It turbocharges enzymes that boost the conversion of NAD+ precursors to NAD+ while also suppressing the activity proteins that deplete NAD+. While you may be familiar with NAD+ supplements for longevity. This product has been designed to also help modulate inflammation and reduce lipids in our blood associated with heart disease. Compared to placebo, at a dose of only 312mg daily, NAD3® lead to significant changes in multiple cardiovascular risk factors (-19%VLDL, -16%LDL, -12%Tot Chol) with a safe, well-tolerated dietary supplement that also demonstrated multiple additional benefits related to healthy aging and cellular longevity. NAD3® may improve NAD+ status by supporting its synthesis and limiting its degradation, in addition to activating the downstream signaling pathways of longevity, while minimizing the chronic stress of aging. The end result is to try to slow down biological aging by playing both “offense” (amplifying the stress-resilience/ longevity genes), and “defense” (by mitigating the molecular and biochemical hallmarks of aging). A recent published study demonstrated NAD3® can positively alter molecular markers related to lipid metabolism, cardiometabolic health and hallmarks of aging. NAD3® is a multi-mechanistic solution for healthy aging, mitochondrial performance, cellular longevity. Second, we have designed ingredient combinations to help with some of the physical components of heart health such as blood pressure and blood viscosity. For this we have included NSK-SD® (Nattokinase) as an ingredient to help support healthy levels of inflammation, reduce the potential for clots, and to optimize blood pressure backed by over 30 published studies over 25 years of research. This natural ingredient purified from soybeans has shown to reduce systolic blood pressure by 13.55 points in just 4 weeks. In vitro experiments and human studies suggest that nattokinase may improve blood flow, decrease blood viscosity, reduce the stickiness of red blood cells, and inhibit platelet aggregation. Cardio NAD+ also includes AmealPeptide® which was discovered over the course of around 40 years of continuous research into the physiological functions of fermented milk, produced during the process of manufacturing the lactic acid drink CALPIS®. AmealPeptide® consists of two lactotripeptides - Valine-Proline-Proline (VPP) and Isoleucine-Proline-Proline (IPP). Key features include its blood pressure-lowering effects and ability to improve cardiovascular functions. AmealPeptide® has an inhibitory activity against angiotensin converting enzyme (ACE). It works on blood vessels by inhibiting enzymes that cause elevated blood pressure and by stimulating production of nitric oxide (NO), which helps to protect blood vessels. These two peptides have substantial effects on improving vascular endothelial dysfunction, vasodilatation, decreases muscle soreness and improves blood flow throughout the body. In addition to this, a newer version of curcumin called tetrahydrocurcumin (4-HC) as been added. It has been documented that curcumin has many cardiovascular benefits. Tetrahydrocurcumin is more bioavailable and as a result, supports better reductions in inflammation. Studies show that tetrahydrocurcumin yields a significant reduction in serum and liver cholesterol, triglycerides, and free fatty acids while supporting healthy levels of inflammation. It also reduces VLDL and LDL cholesterol levels and is more active than curcumin for antihyperlipidemic effects. Citrus Bergamot, an aromatic fruit from southern Italy, has been added to the formula. Bergamot has been shown to support a variety of cardio-metabolic biomarkers such as cholesterol, triglycerides, LDL and HDL in several studies. This combination of natural ingredients provides the best protection for one of the largest causes of death in the world by supporting lipids, improving cardiovascular mechanics by optimizing blood pressure and helping resolve systemic inflammation.

Cardio NAD+ Product Details

Brain Boost+

Brain Boost+ is a powerful combination of paraxanthine, alpha-GPC, lion’s mane, N-acetyl L-tyrosine (NALT) and L-Theanine help to increase energy levels, cognitive function, motivation, and focus all while reducing fatigue. Brain Boost+ may also aid in the prevention of age-related cognitive decline and has neuroprotective properties without the jitters or crash. The ingredients included in Brain Boost+ have shown positive changes in brain wave activity specifically delta and theta waves which are associated with focus and decision making under pressure, making it the ideal formula to utilize when needing a desired edge. Paraxanthine (enfinity®) is caffeine’s primary metabolite in the human body, contributing to the vast majority of caffeine’s beneficial effects. It is a central nervous system stimulant without the toxicity associated with caffeine and has shown greater benefits than caffeine itself. Caffeine has numerous issues with the gene (CYP1A2, caffeine metabolizer gene), where some are slow metabolizers and deal with much of the side effects and fast metabolizers get little of the benefits. Only about 30% are ideal metabolizers of caffeine leading to much diversity in how it is experienced. When ingested, enfinity® functions more consistently than caffeine, leading to fewer side effects, greater enjoyability, improved mood, and a more focused mindset. Multiple studies have shown those benefits to include: <ul> <li>Energy, focus, and wakeful clarity.</li> <li>Enhanced mood and sense of wellbeing.</li> <li>Neuroprotective cognitive accelerant.</li> <li>Improved reaction time and reduced mental errors.</li> <li>Increased caloric expenditure and thermogenesis.</li> <li>Significantly lessened side effects of caffeine with dramatically reduced toxicity.</li> <li>More consistent results: eliminates caffeine’s genetic variability, reducing crashes and anxiety.</li> </ul> Alpha-GPC or Alpha-Glycerophoscholine, is a natural compound found in the brain that also exists in small amounts in certain foods. It’s known for its potential cognitive enhancement and physical performance properties. GeniusPure®Alpha-GPC is a new breakthrough version, 90% yield that is engineered to be hygroscopically stable. Various studies show alpha-GPC supports cognitive function, memory and learning. Alpha-GPC is a precursor to acetylcholine, a neurotransmitter critical for brain health and crosses the blood-brain barrier. Lion’s Mane (Hericium erinaceus) is a type of mushroom that has been used in traditional medicine for its potential health benefits especially for the brain. Lion’s Mane contains compounds that may stimulate the production of nerve growth factor (NGF) in the brain. NGF is involved in the growth, maintenance, and survival of neurons. By promoting NGF production, Lion’s Mane may support brain health and cognitive function. N-acetyl L-tyrosine (NALT) is a modified form of the amino acid L-tyrosine. Tyrosine is a precursor to several important neurotransmitters, including dopamine, norepinephrine, and epinephrine. These neurotransmitters play key roles in mood regulation, focus, attention, stress support and cognitive function. L-Theanine is an amino acid known for its calming effects and potential benefits for relaxation, focus and cognitive function. It is known to have a synergistic effect when paired with paraxanthine promoting alertness and focus without the jittery side effects often associated with caffeine use. L-Theanine can cross the blood-brain barrier and affect various neurotransmitters in the brain such as GABA, serotonin and dopamine. It is also known to increase alpha brain wave activity which is associated with a relaxed but alert mental state.

Brain Boost+ Product Details

BPC+PEA 500

BPC+PEA 500 is a synergistic blend of highly orally bio-available BPC-157 (Arginine Salt) with Palmitoylethanolamide (PEA) and added Salcaprozate sodium (SNAC) for enhanced absorption. This is an ideal formula for anyone looking to support full body repair and regeneration. The peptide BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more. BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders. One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable. We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions. Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy. Palmitoylethanolamide (PEA) is an 18-carbon long- chain fatty acid. Nobel Prize winner Levi-Montalcini identified PEA as a naturally occurring molecule, describing its value in treating chronic infections and pain. Following her discovery, hundreds of scientific studies have been published to show that it is very effective and safe to use. PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system. Its mechanism of action is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs). Palmitoylethanolamide (PEA) is the body’s go-to- molecule and is made on demand when required under disease conditions. This naturally occurs to help resolve inflammation and pain to restore the body to a normal, health state. Due to its ubiquitous nature and presence in all cells, PEA has wide-ranging therapeutic applications. Some of the most common clinical applications are analgesic effects, chronic pain, and inflammation support. PEA has anti-inflammatory effects on the body by inhibiting the production of pro-inflammatory cytokines and by reducing the activity of activated microglia cells. It is also thought to reduce pain by modulating the neurotransmitters involved in pain signaling. In addition to its analgesic and anti-inflammatory effects, PEA is also thought to offer neuroprotection by reducing the levels of reactive oxygen species and by modulating cell death pathways. It has also been shown to improve cognitive function in animal models of Alzheimer's disease. The endocannabinoid system is involved in a wide range of physiological processes, including digestion. The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation. PEA is one of the most abundant endocannabinoids in the gut and is thought to play a key role in gut-brain axis. The endocannabinoid system is known to be involved in various digestive disorders, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Several studies have shown that PEA is effective in reducing symptoms of IBS, such as abdominal pain and bloating. A recent clinical trial showed that a PEA-based product was able to significantly reduce IBS symptoms in patients who did not respond to standard therapy. PEA has also been shown to be effective in supporting other digestive disorders such as GERD and IBD. In a clinical trial, PEA was able to significantly reduce symptoms of GERD, such as heartburn and acid reflux.

BPC+PEA 500 Product Details

BPC-157

BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more. BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders. One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable. We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions. Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy.

BPC-157 Product Details

Phosphatidylserine 150

PS 150 features 150 mg of non-soy, sunflower-sourced phosphatidylserine (PS) per capsule. There are no foods rich in PS, so supplementation is essential in order to increase the bodys levels of this brain-supportive nutrient. Helps regulate cortisol levels. Made with non-GMO ingredients. As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.

Phosphatidylserine 150 Product Details

SAMe

S-Adenosylmethionine (SAMe) is the active methyl form of the amino acid methionine. SAMe is necessary for an array of biochemical pathways, including neurotransmitter synthesis, metabolism of homocysteine, and detoxification. As a donator of methyl groups, SAMe supports glutathione production, liver health, musculoskeletal and joint comfort, and a positive mood. SAMe is a principle methyl donor for biochemical reactions throughout the body. This methyl transfer is critical to reactions involving proteins, phospholipids, DNA, RNA, creatine, hormones, development of cell membranes, degradation of histamine, and formation of norepinephrine and dopamine. Suggested Use: 1-2 capsules two times per day or as recommended by your health care professional.

SAMe Product Details

Methyl Charge+

Methyl Charge+ Product Details

AMPK Charge+

This innovative phytonutrient blend is designed to support the AMPK pathway, a critical metabolic pathway that modulates inflammation, revitalizes cellular health, burns body fat, and promotes longevity. This potent formula allows individuals to activate AMPK, reaping the health-promoting benefits of this ancient signaling pathway. Use on its own, or along with intermittent fasting and carb restriction to maximize their effects. AMPK is an evolutionary metabolic pathway important for blood sugar balance, healthy body weight, detoxification, and longevity that can be activated by exercise, caloric restriction, and fasting mimetics. AMPK Charge+ is a powerful blend of well-researched fasting mimetics and other phytonutrients designed to help activate the AMPK pathway, flipping the body’s “metabolic switch” from sugar to fat burning. This targeted nanoemulsified formulation also supports ketone production, balanced energy, mitochondrial health, and healthy body weight. Benefits: <ul> <li>Supports ketone production and fat breakdown</li> <li>Activates anti-aging pathways and cellular autophagy</li> <li>Supports healthy blood sugar and energy levels</li> <li>Aids in healthy inflammatory response</li> <li>Helps in daily detoxification</li> <li>Supports metabolic clarity</li> <li>Uses patent-pending Quicksilver Scientific Delivery Systems(R) technology to create small, stable delivery vesicles (between 20-70 nm) that begin absorbing as soon as they hit the mouth.*</li> <li>The difference is clear: this product’s liquid transparency can only be achieved with nanoparticles that are smaller than wavelengths of light.*</li> </ul> Resveratrol – Resveratrol is a fasting mimetic phytocompound that has been shown to stimulate AMPK, activate sirtuins, and support autophagy. Resveratrol works synergistically with cellular NAD+ and mitochondrial biogenesis, supporting robust cellular energy production. Berberine – Berberine is a bioactive compound, best known for supporting healthy blood sugar metabolism. Berberine supports AMPK activation and aids in safeguarding the liver by supporting healthy fat breakdown. Quercetin – Quercetin is a versatile fasting mimetic phytonutrient that has been shown to support several aspects of metabolism and healthy aging. It is a powerful antioxidant due to its role in AMPK activation. Research shows that quercetin supports mitochondrial biogenesis and is a powerful immune-modulating compound. It has been well studied as a senolytic supporting healthy cellular senescence. Milk Thistle – Milk Thistle, or Silybum marianum, is a revered member of the traditional herbal medicine compendium. Silymarin, a group of active phytochemicals in milk thistle, supports AMPK activity and has been shown to restore healthy NAD+ levels in the liver. Diindolylmethane (DIM) – DIM is a compound derived from indole-3-carbinol, which is found in cruciferous vegetables. DIM has been shown to influence healthy gene expression by activating AMPK. It also plays a role in supporting a healthy immune response and the upregulation of detoxification pathways. Cinnamon – Cinnamon bark oil is a warming, aromatic essential oil derived from Cinnamomum cassia bark. Cinnamon has been shown to activate AMPK, support healthy lipid levels, help regulate blood sugar, and have cardio-protective properties. Use Alone or With Fasting – This formula complements intermittent fasting and keto or carb-restricted diets (and may allow for more flexible fasting protocols).

AMPK Charge+ Product Details