Telomere Prime
<p data-mce-fragment="1"><span data-mce-fragment="1">As the science of longevity continues to evolve, more and more researchers are focusing on geroprotectors- compounds capable to have the potential to prevent or even reverse aging at the cellular level. Telomere Prime reflects cutting-edge science, featuring a broad spectrum of ingredients that have been shown to support healthy cellular function. The health of our cells is foundational to our overall health, so supporting our health and vitality is one of the smartest things we can do for our long-term wellbeing. The compounds in Telomere Prime have been carefully chosen for their ability to protect and repair DNA, reduce telomere shortening and support healthy cellular function. Telomere Prime supports </span><span data-mce-fragment="1">genomic stability and other</span><span> </span><span data-mce-fragment="1">key indicators of healthspan and lifespan such as, antioxidant protection, body global cell health, inflammation support, and mitochondrial function.</span></p> <p data-mce-fragment="1"><strong>Featured Benefits: </strong></p> <ul data-mce-fragment="1"> <li data-mce-fragment="1"><span data-mce-fragment="1">Support the body’s natural ability to repair its own DNA. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Significantly increases telomere length in yearlong clinical trials. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Inhibit synthesis of pro-inflammatory “inflammaging” cytokines such as interleukin (IL)-6, (IL)-8, NF-KB and TNF-alpha. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Prevent cell death through inhibition of the pro-apoptotic factors. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Support your DNA’s defenses against free radical damage and activates NRF2</span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Activates the cell and mitochondrial renewal process</span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Chelate divalent metal ions. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Protect against damage caused by the prooxidants ferric-NTA and β-amyloid. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Enhance the immune system by increasing the life cycle of white blood cells. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Helps reduce DNA and mitochondrial damage and protect against free radicals. </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Protect against UV and gamma radiation by neutralizing radiation-induced reactive oxygen species (ROS). </span></li> </ul> <p><br></p> <p data-mce-fragment="1"><b data-mce-fragment="1">ac-11® Cat's Claw Aqueous Extract (Uncaria tomentosa)</b></p> <p data-mce-fragment="1"><b data-mce-fragment="1">ac-11®</b><span data-mce-fragment="1"> is an all-natural, safe, and effective aqueous extract of </span><i data-mce-fragment="1"><span data-mce-fragment="1">Uncaria tomentosa</span></i><span data-mce-fragment="1">, a medicinal plant indigenous to the Amazon rainforest. Manufactured using a proprietary process, this extract provides a broad spectrum of health benefits, primarily directed towards systemic DNA repair, environmental stress, infection, immunosenescence and aging. </span><span data-mce-fragment="1"><br data-mce-fragment="1"></span><span data-mce-fragment="1"><br data-mce-fragment="1"></span><span data-mce-fragment="1">Scientists have determined that when the body is subjected to external stressors such as overexposure to the Sun (UV radiation), strenuous exercise, pollution, and/or the general effects of aging, our DNA is damaged. Such cumulative DNA damage has been scientifically confirmed as a causative factor in the age-onset disease. </span><span data-mce-fragment="1"><br data-mce-fragment="1"></span><span data-mce-fragment="1"><br data-mce-fragment="1"></span><span data-mce-fragment="1">In a series of peer-reviewed scientific and clinical studies conducted by third-party laboratories and university medical centers, </span><b data-mce-fragment="1">ac-11®</b><span data-mce-fragment="1"> has been proven to help the body’s natural ability to repair its own DNA. The primary active ingredients of </span><b data-mce-fragment="1">ac-11®</b><span data-mce-fragment="1"> are formed by the complex molecular chains known as CAEs (Carboxy Alkyl Esters). CAEs are responsible for approximately 90% of </span><b data-mce-fragment="1">ac-11®</b><span data-mce-fragment="1">’s therapeutic benefits. Studies demonstrate that this patented technology: </span><span data-mce-fragment="1"><br data-mce-fragment="1"><br data-mce-fragment="1"></span></p> <ul data-mce-fragment="1"> <li data-mce-fragment="1"><span data-mce-fragment="1">Increases telomere length in a cell (Patent No.: US 10,098,922B1)</span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Helps the body’s natural ability to repair its own DNA </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Enhances the immune system by increasing the life cycle of white blood cells</span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Repairs neural function damaged by overexposure to high decibel noise</span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Helps to normalize the expression of NF-KB, thereby regulating the cellular response to systemic inflammation</span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Maintains telomere length and integrity during the process of cellular mitosis </span></li> <li data-mce-fragment="1"><span data-mce-fragment="1">Increases production of natural collagen III, a form of collagen associated with soft, supple, youthful-looking skin </span></li> </ul> <p data-mce-fragment="1"><b data-mce-fragment="1">ac-11®</b><span data-mce-fragment="1"> differs from all other </span><i data-mce-fragment="1"><span data-mce-fragment="1">Uncaria tomentosa</span></i><span data-mce-fragment="1"> extracts, most of which are sold under the common name “cat’s claw,” in that its molecular composition is distinct. Such distinction is achieved through an ultra-filtration process that produces a low weight (less than 10,000 Daltons) bioavailable, scientifically indole alkaloid free (less than 0.05 ppm) extract. </span><span> </span><span data-mce-fragment="1">The inner bark of the plant (</span><i data-mce-fragment="1"><span data-mce-fragment="1">Uncaria tomentosa</span></i><span data-mce-fragment="1">) used to manufacture </span><b data-mce-fragment="1">ac-11®</b><span data-mce-fragment="1"> is harvested in the Amazon rainforests of Brazil and Peru utilizing an eco-friendly and renewable process. </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">2-HOBA (as Hobamine</b><b data-mce-fragment="1">®</b><b data-mce-fragment="1">)</b></p> <p data-mce-fragment="1">Hobamine<span data-mce-fragment="1">™, or 2-hydroxybenzylamine (2-HOBA), is a naturally occurring compound in Himalayan Tartary Buckwheat that is at the forefront of new developments to support cellular health, particularly as we age. </span><span data-mce-fragment="1">Hobamine</span><span data-mce-fragment="1">™</span><span> </span>(2-HOBA) works by rapidly capturing specific reactive compounds formed by oxidative stress. This capture prevents those compounds from binding to and damaging other cellular components like proteins, lipids, or DNA and impeding normal function of the cell. </p> <p data-mce-fragment="1"><span data-mce-fragment="1">An NIH-funded study found that Hobamine™ supplementation led to positive changes in 15 inflammatory biomarkers associated with immune system balance in both younger and older adults. Hobamine™ works by scavenging pro-inflammatory reactive lipids, helping maintain immune homeostasis, and supporting your immune system's ability to stay in balance even when exposed to oxidative stressors. </span><span data-mce-fragment="1">Hobamine</span><span data-mce-fragment="1">™</span><span> </span>has been shown to promote normal cell function in brain cells, blood vessels, and heart, lung, and immune cells from the effects of oxidative stress, which helps to support healthy function. Hobamine<span data-mce-fragment="1">™</span><span> </span>is an emerging solution for anyone experiencing the signs of premature aging due to oxidative stress.</p> <p data-mce-fragment="1"><b data-mce-fragment="1">L-Ergothioneine (as MitoPrime®)</b></p> <p data-mce-fragment="1"><span data-mce-fragment="1">Ergothioneine is an amino acid — a building block to proteins — that is synthesized by bacteria and fungi, leading mushrooms to be the primary dietary source. S</span><span data-mce-fragment="1">ince its discovery, the unique properties of the, ergothioneine has intrigued researchers for more than a century. Emerging research shows that it is a full spectrum cyto-restorative that protects and repairs the complete cell, including DNA and mitochondria, from the full array of assaults both endogenous and exogenous. Ergothioneine is an antioxidant concentrated in mitochondria, suggesting a specific role in protecting mitochondrial components such as DNA from oxidative damage. Ergothioneine is readily absorbed after oral supplementation, resulting in significant increases in plasma and whole blood ergothioneine levels </span></p> <p data-mce-fragment="1"><span data-mce-fragment="1">In</span><span data-mce-fragment="1"> one study</span><span data-mce-fragment="1"> using cells exposed to oxidative conditions found that ergothioneine treatment significantly lengthened telomeres and reduced the percentage of shortened telomeres after eight weeks. Treating the cells with </span><span data-mce-fragment="1">ergothioneine </span><span data-mce-fragment="1">also boosted the activity of telomerase which is the only enzyme that maintains telomere length.</span></p> <p data-mce-fragment="1"><span data-mce-fragment="1">Another</span><span data-mce-fragment="1"> recent publication</span><span data-mce-fragment="1"> investigated how ergothioneine levels relate to mortality. The looked at levels of 112 compounds in the blood of 3,200 Swedish adults, ergothioneine exhibited the strongest connection with reduced mortality — higher levels of the compound markedly reduced the risk of all-cause mortality, cardiovascular-related mortality, or developing heart disease at all. Due to the recent published research, </span><span data-mce-fragment="1">ergothioneine is being referred to as the ‘longevity vitamin’. </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Spermidine (as Puremidine®)</b></p> <p data-mce-fragment="1"><span data-mce-fragment="1">Spermidine is a polyamine compound found naturally in most living organisms and certain foods. It has been studied for its potential health benefits since the early 1970’s. Spermidine is believed to have anti-aging properties that can protect against cellular damage and enhance cell function. Research has shown that it may improve heart health, increase longevity, and support healthy inflammation levels through the body. Studies have also demonstrated that spermidine can help boost cognitive function and memory by stimulating the release of brain-derived neurotropic factor (BDNF) and increasing the number of synaptic connections in the brain. Another potential benefit of spermidine is its ability to reduce oxidative stress and improve mitochondrial function. Spermidine has been shown to help protect our cells from damage of aging, which leads to a host of age-related disease. Research has shown that when spermidine is supplemented, it can help lengthen telomeres and restore their protective effects. It also helps improve cell metabolism, which can result in increased energy production and better overall health. </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Sulforaphane Glucosinolate (as Activated BroccoRaphanin®)</b></p> <p data-mce-fragment="1"><span data-mce-fragment="1">Sulforaphane is a type of isothicyanate and a metabolite of glucoraphanin which is a phytonutrient found in cruciferous vegetables, such as broccoli, brussels sprouts, and cabbage. Studies have suggested that consumption of sulforaphane can provide numerous health benefits, such has reducing oxidative stress and supporting inflammation levels. In addition to its potential therapeutic effects sulforaphane has been studies for its ability to enhance the body’s natural defense mechanisms. It has been shown to activate enzymes that help protect cells and DNA from damage. Studies have also suggested that sulforaphane may play a role in enhancing the body’s natural detoxification process, helping to flush out harmful toxins from cells. The myrosinase enzyme added into Telomere Prime is necessary for the conversion of glucoaphanin to sulforaphane. The enzyme is released by the plant upon chewing or chopping and is responsible for activating sulforaphane.</span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Buckwheat Peptides</b></p> <p data-mce-fragment="1"><span data-mce-fragment="1">The protein isolated from buckwheat have been hydrolyzed into a range of peptides. These peptides showed diverse biological activities in vitro and in vivo. They include trypsin inhibition, anti-aging, modulating gut microbiota, heart, and immune support. </span></p> <p data-mce-fragment="1"><span data-mce-fragment="1">Telomere Prime showcases the latest advancements in healthy aging support and features ac-11 Cat’s Claw, 2-hoba, L-ergothioneine, spermidine, sulforaphane with myrosinase and buckwheat peptides. </span><span data-mce-fragment="1"> </span><span data-mce-fragment="1">It is the perfect way to give your cells the boost they need to stay health and support your overall health as you age. So, if you are looking for a natural way to support your longevity, Telomere Prime is part of your solution.</span></p>
Telomere Prime Product DetailsRejuvenate (Senolytic)
<p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Cellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses.<span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">This has numerous implications for the body, including its ability to adapt to changes in its environment, as well as its capacity to regenerate itself. This<span data-mce-fragment="1"> </span>can be beneficial for individuals to understand how cellular senescence works and what the potential benefits are for the body. Firstly, understanding cellular senescence can help us better understand aging, as this process is a major contributor to the aging process. Additionally, it can also provide insight into certain diseases and conditions that may be linked to the inability of cells to divide and proliferate properly. Finally, by targeting cellular senescence, we may be able to find new ways of fighting against aging and diseases associated with it. Thus, understanding ways to best support cellular senescence can be a powerful tool in our pursuit of longevity and improved health span. <span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">Senolytics, are small molecules that can selectively kill senescence cells and have been developed to support various age-related diseases while also extending healthspan. In recent years, emerging natural compounds have been discovered to be effective senolytic agents that are featured in this breakthrough formula. Clearance of senescent cells can support the reduction of inflammation, decrease macromolecular dysregulation, and enhance function of stem and progenitor cells.</span></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1"><strong>Rejuvenate</strong><span> </span>presents a unique solution for intervention through two mechanisms: </span></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">(1) eliminating senescent cells (senolytics) </span></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1"> (2) inhibiting of senescent- associated secretory phenotype (SASP) </span></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Featured benefits: </span></p> <ul data-mce-fragment="1"> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Once weekly pulsed high dosing blend of senolytics which have been shown to reduce senescent cells in vivo.</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Targets aging at the cellular level</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Induces autophagy to promote intracellular recycling and cellular renewal</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Reduce full body features of Senescence-Associated Secretory Phenotype (SASP).</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Protects cells against free radicals and oxidative stress </span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Targets inflammaging at the cellular level and supports a healthy inflammatory response</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Supports a healthy immune system </span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Formula designed to also treat muscle senescence.</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Exercises muscles longer and harder with a boost in citrate synthase activity.</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Recovers more effectively with a reduction in inflammation biomarkers.</span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Decreases SA-β-Gal by 63% in muscle tissue.</span></li> </ul> <p data-mce-fragment="1"><b data-mce-fragment="1">Fisetin:</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Fisetin is a polyphenol found in many fruits and vegetables, including strawberries,<span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">apples, and onions. It has been studied for its potential benefits related to aging. Fisetin has shown great promise to inhibit senescence due to its ability to act on numerous biological processes. Studies have shown that fisetin is the most natural senolytic agent that can protect cells from oxidative damage, protecting them against age related diseases and reduce senescence markers in multiple tissues. </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Quercetin Phytosome:</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Quercetin is one of the most studied dietary flavonoids ubiquitously present in various vegetables. A key feature of quercetin is its strong antioxidant activity which potentially enables it to quench free radicals from forming resonance-stabilized phenoxyl radicals. However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology is the preferred delivery system to overcome these limitations. This enhanced form of quercetin has been shown to be 20 times better absorbed than other quercetin options. </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Spermidine:</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Spermidine has emerged as an important metabolite that links cellular aging and autophagy. Spermidine is a naturally occurring polyamine involved in biological processes such as cell growth and proliferation, tissue regeneration and translation regulation, making it a critical regulator of cellular homeostasis. Spermidine also exhibits anti-inflammatory and anti-aging properties. External supplementation of spermidine improves longevity, which may be attributed to its ability to exert cardioprotective and neuroprotective effects, as well as reducing immune senescence. </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Senactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) extracts containing </b><b data-mce-fragment="1">ginsenoside Rg1:</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Senactiv® promotes more energy and muscle preservation by activating phagocytic macrophages in association with the senescent cell clearance in muscle tissue after aerobic exercise. It's composed of two highly purified and fractionated extracts from </span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Panax notoginseng </span></i><span style="font-weight: 400;" data-mce-fragment="1">and </span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Rosa rugosa. </span></i><span style="font-weight: 400;" data-mce-fragment="1"> Research suggests that this combination is a potent senolytic. Muscle samples taken before and after exercise shows that Senactiv® supplementation resulted in significantly fewer amounts of detectable<span> </span></span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">β-</span></i><span style="font-weight: 400;" data-mce-fragment="1">galactosidase-tagged cells which is a <span> </span><span data-mce-fragment="1">method to assess cellular </span><em data-mce-fragment="1">senescence</em></span><span style="font-weight: 400;" data-mce-fragment="1">. <span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">In a recent </span><span style="font-weight: 400;" data-mce-fragment="1">Senactiv®</span><span style="font-weight: 400;" data-mce-fragment="1"> human clinical study confirmed, though exercise generally increases the movement of white blood cells and “clean up” cells into the muscle, it does not always activate phagocytosis to clear away the broken down apoptotic cells and senescent cells . With Senactiv</span><span style="font-weight: 400;" data-mce-fragment="1">®, phagocytosis activation can clear these types of cells away leading to the decrease in both apoptotic and senescent cells in active muscles.</span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">TurmiPure GOLD®</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Turmeric (Curcuma longa L.) has been used in India for more than 5,000 years as a spice and medicinal herb in traditional ayurvedic medicine. Well-known for its anti-inflammatory properties, it is now recognized as the #1 botanical for healthy aging. However, its poor bioavailability (number of actives reaching the blood stream) in curcuminoids lowers its efficacy and its poor solubility limits its application (often limited to capsules and tablets), therefore high intake (~1500mg) of standard turmeric extract was shown to be efficient.</span></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">After 5 years of research, our partner has overcome these issues by developing TurmiPure GOLD®, the world’s first bioequivalent turmeric at a low dose of 300mg. Its innovative formulation highly enhances the bioavailability of curcuminoids 24X, in addition to being instantly water dispersible. A dose of 300mg of TurmiPure Gold® delivers as many curcuminoids in blood as 1922mg of standard turmeric 95% curcuminoids (with or without addition of 1% black pepper extract standardized to 95% piperine). Curcuminoids are clinically proven to be effective in more than 100 studies to support: healthy joint function (including inflammatory response), normal bile production and overall body function, contributing to healthy aging conditions. Curcumin has shown p</span><span style="font-weight: 400;" data-mce-fragment="1">romise to mitigate the senescence</span><span style="font-weight: 400;" data-mce-fragment="1">-associated secretory phenotype (</span><span style="font-weight: 400;" data-mce-fragment="1">SASP</span><span style="font-weight: 400;" data-mce-fragment="1">) and</span><span> </span><span style="font-weight: 400;" data-mce-fragment="1">its aging-induction consequences of senescent cells.</span></p> <br data-mce-fragment="1"> <p data-mce-fragment="1"><b data-mce-fragment="1">Tetrahydrocurcumin (CurcuPrime</b><span style="font-weight: 400;" data-mce-fragment="1">®</span><b data-mce-fragment="1">) </b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Tetrahydrocurcumin (4-HC) is the key</span><span> </span><span style="font-weight: 400;" data-mce-fragment="1">bioactive derivative</span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1"> </span></i><span style="font-weight: 400;" data-mce-fragment="1">of curcumin and with advances in science, it’s also given credibility as the </span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">engine</span></i><span style="font-weight: 400;" data-mce-fragment="1"><span> </span>behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. </span><span style="font-weight: 400;" data-mce-fragment="1">Researchers have also confirmed that<span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">4-HC attenuated pro-inflammatory indicators</span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1"> like </span></i><span style="font-weight: 400;" data-mce-fragment="1">interleukin-1, interleukin-6, TNF-</span><span style="font-weight: 400;" data-mce-fragment="1">⍺</span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">, and </span></i><span style="font-weight: 400;" data-mce-fragment="1">prostaglandin E2.</span></p> <br data-mce-fragment="1"> <p data-mce-fragment="1"><b data-mce-fragment="1">Apigenin:</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Apigenin is a natural bioactive plant polyphenol with antioxidant, anti-inflammatory and immune system boosting properties. It also helps to support against oxidative stress for better cellular function. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels. Apigenin is known to induce apoptosis in a p53-independent pathway by enhancing oxidative stress. The p53-independent apoptotic effects of apigenin would support its use as a senolytic </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Luteolin:</b><span style="font-weight: 400;" data-mce-fragment="1"><br data-mce-fragment="1"></span><span style="font-weight: 400;" data-mce-fragment="1">Luteolin is a flavonoid naturally found in plants. Flavonoids like luteolin have been found to have beneficial effects on human health by reducing oxidative stress. </span><span style="font-weight: 400;" data-mce-fragment="1">Luteolin, which acts as the first-line defense system in plants against adverse photobiological effects such as protection against UV radiation, has shown promising senotherapeutic effects </span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">Green Tea containing epigallocatechin gallate (EGCG)</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1"> The phytochemical epigallocatechin gallate (EGCG) is the major catechin found in green tea, with many potential benefits on health outcomes, including cell senescence, aging, and age-related diseases. Preclinical evidence suggests that EGCG exhibits promising senolytic and senomorphic effects through multi-faceted mechanisms, including targeting apoptotic pathways, cell cycle regulation, nutrient sensing pathways, SASP, and oxi-inflammatory stress pathways.</span></p> <p data-mce-fragment="1"><b data-mce-fragment="1">AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing </b><b data-mce-fragment="1">astragaloside I, II, IV and ginsenoside Rb1:</b></p> <p data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">AstraGin</span><span style="font-weight: 400;" data-mce-fragment="1">®</span><span style="font-weight: 400;" data-mce-fragment="1"><span> </span>is a proprietary plant derived compound complex extracted by a proprietary pharmaceutical extraction and processing technology. AstraGin</span><span style="font-weight: 400;" data-mce-fragment="1">®<span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">upregulates mRNA and protein expression levels of nutrient transporters that regulate the absorption of nutrients and plant compounds in the gut. AstraGin</span><span style="font-weight: 400;" data-mce-fragment="1">®<span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">has shown in 16<span> </span></span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">in-vitro<span> </span></span></i><span style="font-weight: 400;" data-mce-fragment="1">and 8<span> </span></span><i data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">in-vivo<span> </span></span></i><span style="font-weight: 400;" data-mce-fragment="1">studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to: </span></p> <ul data-mce-fragment="1"> <li style="font-weight: 400;" data-mce-fragment="1"> <span style="font-weight: 400;" data-mce-fragment="1">Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. One example is AstraGin</span><span style="font-weight: 400;" data-mce-fragment="1">®<span> </span></span><span style="font-weight: 400;" data-mce-fragment="1">has been shown to increase curcumin absorption by 92%.</span> </li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS- induced colitis rats. </span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate. </span></li> <li style="font-weight: 400;" data-mce-fragment="1"><span style="font-weight: 400;" data-mce-fragment="1">May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut- associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages. </span></li> </ul>
Rejuvenate (Senolytic) Product DetailsLongevity
<p><span face="arial, sans-serif">Biological aging is directly impacted by physiological integrity. Muscle strength, mass, function, quantity, and quality loss are some of the main issues associated with the process of aging. As we age the performance of our muscle cells decline which leads to a weakened immune system, sarcopenia, obesity, and chronic disease among much more. Healthgevity has selected<strong> PeptiStrong™, <wbr>Senactiv® and AstraGin® </wbr></strong>which are all clinically proven ingredients to put your muscles in the best position to thrive regardless of your age.</span></p> <p><span face="arial, sans-serif">In a recent study it was concluded that lower muscle strength in late adolescence showed direct connection with higher risk of chronic disease. As such, skeletal muscle might be the central integrator between sarcopenia, obesity, immune senescence and more in an aging biological system. Preserving muscle mass is critical for optimizing health span. Research shows the strongest one-third of the population over the age of 60 has a 50% lower death rate than the weakest, making muscle a key predictor of longevity. Recent discoveries of clinically proven ‘growth promoting’ ingredients have made the process of building and preserving muscle more obtainable. </span></p> <p><span><strong data-mce-fragment="1">PeptiStrong</strong><b data-mce-fragment="1">™</b>,</span><span><strong> Senactiv®</strong> and <strong>AstraGin®</strong></span><span> work synergistically to target multiple mechanisms, to provide a wide range of benefits in muscle health. </span></p> <p><span><b>PeptiStrong™ (Peptides from hydrolyzed fava bean protein)</b></span></p> <p><span> Through cutting edge Al-precision technology, Nuritas is creating a brand-new category of precision peptide ingredients from nature. Their cell-signaling power helps the body function at its best. Longevity is the first product resulting from Healthgevity's collaboration with Nuritas and contains </span><span><strong>PeptiStrong</strong><b data-mce-fragment="1">™ </b></span><span>: precision peptides that have been clinically proven </span><span>to support muscle health. <strong data-mce-fragment="1">PeptiStrong</strong><b data-mce-fragment="1">™</b></span><span> </span><span>can increase muscle synthesis by supporting mTOR, reduce muscle loss by downregulating muscle atrophy related genes and improve muscle health by reducing inflammation properties.</span></p> <p><span>Backed by two peer-reviewed clinical studies, this plant-based intelligent ingredient has outperformed animal protein. It has a multi-dimensional effect on muscle health: promoting muscle strength, improving recovery after intense exercise, boosting </span><span>energy,</span><span> and supporting the synthesis of protein that assists in maintaining and building muscle</span><span>. </span><span>A 'peptide-specific’ effect to address the muscle homeostasis between muscle protein synthesis, muscle atrophy and inflammation, offers an alternative to a purely uncharacterized nutritional intervention. In the most recent double blind placebo clinical study, <strong>PeptiStrong™ </strong>alone provided: </span></p> <p><br></p> <p><b>Featured<span> </span><strong data-mce-fragment="1">PeptiStrong</strong>™</b><b> </b><b>research benefits: </b></p> <ul> <li><span>Regenerates muscles by increasing the expression of new muscle fibers.</span></li> <ul> <li><span>Type I “Slow Twitch” Muscle Fibers are responsible for endurance and strength endurance. They contain a higher number of mitochondria and utilize fat for energy.</span></li> <li> <span>Type II “Fast Twitch” Muscle fibers are responsible for </span><span>strength and force</span><span> </span><span>production. Loss of Type II fibers is most associated with aging.</span> </li> </ul> <li><span>Reduces muscle loss and fat accumulation</span></li> <li> <span>Reduces </span><span>Tumor Necrosis Factor-alpha (</span><i><span>TNF</span></i><span>-α)</span> </li> <li><span>Improves cellular metabolism through the activation of AMPK which in turn increases the levels of NAD+ and sirtuins</span></li> <li><span>Maintains autophagy in skeletal muscle similar to fasting</span></li> <li><span>Induces mitochondrial biogenesis in the muscle cell</span></li> </ul> <div><img src="https://cdn.shopify.com/s/files/1/0655/5287/5766/files/Screenshot2023-02-09at9.28.50AM_1024x1024.png?v=1675952967"></div> <p><br></p> <p><span><b>Senactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) extracts containing </b><b>ginsenoside Rg1:</b></span></p> <p><strong>Senactiv®<span> </span></strong><span>has over </span><span>10 years of research behind it including 2 in vivo studies and 5 human clinical trials. A recent study confirmed a process to reverse aging in muscle cells. Aging in muscle cells is a function of a cell itself, not being able to divide and repair itself. The process is known as </span><span>cellular senescence</span><span>, and it happens during aging. This study found that by the overexpression of a particular protein called NANOG, the cell does not have be reset to a different state to reverse aging. </span><span>Ginsenoside Rg1 contained in </span><strong>Senactiv®</strong><span>, has the potential to activate expression of NANOG to help in reversing the aging process in skeletal muscle.</span><span> A new mechanism of aging has been uncovered by researchers: the accumulation of sphingolipids. Ceramides, a widely known class of sphingolipids, build up in aging muscle and reduce its function, impacting the functional capacity of older adults. <strong data-mce-fragment="1"> Senactiv®</strong> has the potential to inhibit sphingolipid synthesis prevent age-related decline in muscle mass and reduce its function. </span></p> <p><strong> Senactiv®<span> </span></strong><span>has been also shown to have the potential to: </span></p> <ul> <li>Increase endurance performance</li> </ul> <span></span> <ul> <ul> <ul> <li><span>endurance performance was extended by increasing energy in cells and increasing glycogen replenishment in muscles</span></li> </ul> </ul> </ul> <ul> <li>Speed up muscle fatigue recovery</li> </ul> <span></span> <ul> <ul> <ul> <li><span>speeding up muscle fatigue recovery can be achieved by decreasing muscle inflammation during exercise and accelerating muscle inflammation recovery after exercise</span></li> </ul> </ul> </ul> <ul> <li>Muscle regeneration</li> </ul> <span></span><span></span> <ul> <ul> <ul> <li>muscle regeneration was increased by eliminating senescent cells and increasing new muscle growth</li> </ul> </ul> </ul> <p><span><b>AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing </b><b>astragaloside I, II, IV and ginsenoside Rb1:</b></span></p> <p><strong>AstraGin®<span> </span></strong><span>has been shown to increase intestinal arginine and leucine absorption by 67% and 58%, respectively, which contributes to the activation of the mTOR pathway and suggest increasing the skeletal muscle protein synthesis <span class="zp tsl-16" data-mce-fragment="1">by up to 30%</span>. Recent studies show that the gut-muscle axis is a physiological target for combatting anabolic resistance and reducing risk of sarcopenia.</span></p> <p><strong>AstraGin</strong><span><strong>®</strong> </span><span>has shown in 16 </span><i><span>in-vitro </span></i><span>and 8 </span><i><span>in-vivo </span></i><span>studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to: </span></p> <ul> <li><span>Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. </span></li> <li><span>Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS- induced colitis rats. </span></li> <li><span>May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate. </span></li> <li><span>May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut- associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages. </span></li> </ul>
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